Clinical and psychometric validation of the EORTC QLQ-CR29 questionnaire module to assess health-related quality of life in patients with colorectal cancer

被引：336

作者：

Whistance, R. N. ^{[1
,2
,3
]}

Conroy, T. ^{[4
]}

Chie, W. ^{[5
,6
]}

Costantini, A. ^{[7
]}

Sezer, O. ^{[8
]}

Koller, M. ^{[9
]}

Johnson, C. D. ^{[10
]}

Pilkington, S. A. ^{[10
]}

Arraras, J. ^{[11
]}

Ben-Josef, E. ^{[12
]}

Pullyblank, A. M. ^{[3
]}

Fayers, P. ^{[13
,14
]}

Blazeby, J. M. ^{[1
,2
]}

机构：

[1] Univ Bristol, Dept Social Med, Bristol, Avon, England

[2] Univ Hosp Bristol, NHS Fdn Trust, Div Head & Neck Surg, Bristol, Avon, England

[3] N Bristol Trust, Dept Gen Surg, Bristol, Avon, England

[4] Nancy Univ, Dept Med Oncol, Ctr Alexis Vautrin, EA 4360, Vandoeuvre Les Nancy, France

[5] Natl Taiwan Univ, Sch Publ Hlth, Taipei, Taiwan

[6] Natl Taiwan Univ, Grad Inst Prevent Med, Taipei, Taiwan

[7] Univ Roma La Sapienza, St Andreas Hosp, Psychooncol Unit, Rome, Italy

[8] Charite Univ Med Berlin, Dept Haematol & Oncol, Berlin, Germany

[9] Univ Hosp Regensburg, Ctr Clin Studies, Regensburg, Germany

[10] Southampton Univ Hosp, NHS Trust, Univ Surg Unit, Southampton, Hants, England

[11] Hosp Navarra, Dept Oncol, Pamplona, Spain

[12] Univ Michigan, Dept Radiat Oncol, Ann Arbor, MI 48109 USA

[13] Univ Aberdeen, Div Appl Hlth Sci, Aberdeen, Scotland

[14] Norwegian Univ Sci & Technol, Dept Canc Res & Mol Med, N-7034 Trondheim, Norway

来源：

EUROPEAN JOURNAL OF CANCER | 2009年 / 45卷 / 17期

关键词：

Questionnaire; Quality of life; Colorectal cancer; EORTC; Validation; EUROPEAN-ORGANIZATION; RECTAL-CANCER; FUNCTIONAL ASSESSMENT; INSTRUMENT; ONCOLOGY; TRIALS;

D O I：

10.1016/j.ejca.2009.08.014

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This international study aimed to test the measurement properties of the updated European Organisation for Research and Treatment of Cancer (EORTC) questionnaire module for colorectal cancer, the QLQ-CR29. The QLQ-CR29 was administered with the QLQ-C30, core questionnaire, to 351 patients from seven countries. Questionnaire scaling and reliability were established and clinical and psychometric validity examined. Patient acceptability and understanding were assessed with a debriefing questionnaire. Multi-trait scaling analyses and face validity refined the module to four scales assessing urinary frequency, faecal seepage, stool consistency and body image and single items assessing other common problems following treatment for colorectal cancer. Scales distinguished between clinically distinct groups of patients and did not correlate with QLQ-C30 scales, demonstrating construct validity. The QLQ-CR29 scores were reproducible over time in stable health. The EORTC QLQ-CR29 demonstrates sufficient validity and reliability to support its use to supplement the EORTC QLQ-C30 to assess patient-reported outcomes during treatment for colorectal cancer in clinical trials and other settings. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：3017 / 3026

页数：10

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