Effect of the leu-enkephalin analog dalargin on DNA synthesis in the myocardium and lingual epithelium of rats in early postnatal ontogeny

The DNA synthesis is studied in the myocardium and lingual epithelium of 4-5-day-old rats 24 h after a single administration of the leu-enkephalin analog dalargin in a dose of 10 or 100 mu g/kg. At 10 mu g/kg, dalargin significantly decreases the number of DNA-synthesizing nuclei in the left atrium, while at 100 mu g/kg it significantly decreases the number of DNA-synthesizing nuclei in the left atrium and both ventricles. Dalargin does not change the DNA synthesis in the lingual epithelial cells.