Upregulating promoter polymorphisms of RANTES relate to atopic dermatitis

被引：28
作者：
Tanaka, K.
Roberts, M. H.
Yamamoto, N.
Sugiura, H.
Uehara, M.
Hopkin, J. M.
机构：
[1] Univ Coll Swansea, Sch Med, Expt Med Unit, Swansea SA2 8PP, W Glam, Wales
[2] Shiga Univ Med Sci, Dept Dermatol, Otsu, Shiga 52021, Japan
来源：
INTERNATIONAL JOURNAL OF IMMUNOGENETICS | 2006年 / 33卷 / 06期
关键词：
D O I：
10.1111/j.1744-313X.2006.00635.x
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
It has been reported that a functional polymorphism in the promoter of the RANTES gene (-403G/A) is associated with atopic dermatitis in a German population. Although there are several reports on the association of RANTES promoter polymorphisms (-403G/A and -28C/G) with asthma, the association of these polymorphisms with atopic dermatitis has not yet been confirmed in other populations. We therefore aimed to test whether the RANTES promoter polymorphisms relate to atopic dermatitis in a well-defined Japanese population. We conducted an association study of upregulating promoter polymorphisms of RANTES (-403G/A and -28C/G) in 389 patients with atopic dermatitis and 177 healthy control subjects. There was a significant association between the upregulating variant of RANTES -28G and atopic dermatitis, while -403A variant showed a significant association with atopic dermatitis with high IgE productivity. These results support a role for RANTES promoter polymorphisms in susceptibility to atopic dermatitis.
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收藏
页码：423 / 428
页数：6
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