Potential utility of PPARα activation in the prevention of ischemic and drug-induced acute renal damage

被引：21

作者：

Lopez-Hernandez, Francisco J. ^{[1
,2
]}

Lopez-Novoa, Jose M. ^{[1
]}

机构：

[1] Univ Salamanca, Dept Physiol & Pharmacol, Renal & Cardiovasc Physiopathol Unit, Queen Sofia Inst Nephrol Res, Salamanca 37007, Spain

[2] Hosp Clin Univ, Res Unit, Salamanca, Spain

来源：

KIDNEY INTERNATIONAL | 2009年 / 76卷 / 10期

关键词：

CISPLATIN NEPHROTOXICITY; FAILURE;

D O I：

10.1038/ki.2009.229

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Acute renal failure induced by renal ischemia or drugs continues to be a relevant clinical problem. Li et al. have demonstrated that proximal tubule-restricted peroxisome proliferator-activated receptor-alpha (PPAR alpha) expression in transgenic mice reduced cisplatin- and ischemia/reperfusion-induced acute renal injury. Their article suggests a role for the maintenance of free fatty acid oxidation in the proximal tubule as a mechanism of nephroprotection, as well as a potential clinical utility of PPAR alpha activators in the prevention of acute renal failure. Kidney International (2009) 76, 1022-1024. doi: 10.1038/ki.2009.229

引用

页码：1022 / 1024

页数：4

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