Precision Medicine and Public Health: New Challenges for Effective and Sustainable Health

被引：33

作者：

Traversi, Deborah ^{[1
]}

Pulliero, Alessandra ^{[2
]}

Izzotti, Alberto ^{[3
,4
]}

Franchitti, Elena ^{[1
]}

Iacoviello, Licia ^{[5
,6
]}

Gianfagna, Francesco ^{[5
,7
]}

Gialluisi, Alessandro ^{[6
]}

Izzi, Benedetta ^{[6
]}

Agodi, Antonella ^{[8
]}

Barchitta, Martina ^{[8
]}

Calabro, Giovanna Elisa ^{[9
]}

Hoxhaj, Ilda ^{[9
]}

Sassano, Michele ^{[9
]}

Sbrogio, Luca Gino ^{[10
]}

Del Sole, Annamaria ^{[11
]}

Marchiori, Francesco ^{[12
]}

Pitini, Erica ^{[13
]}

Migliara, Giuseppe ^{[13
]}

Marzuillo, Carolina ^{[13
]}

De Vito, Corrado ^{[13
]}

Tamburro, Manuela ^{[14
]}

Sammarco, Michela Lucia ^{[14
]}

Ripabelli, Giancarlo ^{[14
]}

Villari, Paolo ^{[13
]}

Boccia, Stefania ^{[15
]}

机构：

[1] Univ Torino, Dept Publ Hlth & Pediat, Piazza Polonia 94, I-10126 Turin, Italy

[2] Univ Genoa, Sch Med, Dept Hlth Sci, I-16132 Genoa, Italy

[3] Univ Genoa, Dept Expt Med, I-16132 Genoa, Italy

[4] IRCCS Osped Policlin San Martino, I-161632 Genoa, Italy

[5] Univ Insubria, Dept Med & Surg, Res Ctr Epidemiol & Prevent Med EPIMED, I-21100 Varese, Italy

[6] IRCCS NEUROMED, Dept Epidemiol & Prevent, I-86077 Pozzilli, Italy

[7] Mediterranea Cardioctr, I-80122 Naples, Italy

[8] Univ Catania, Dept Med & Surg Sci & Adv Technol GF Ingrassia, I-95123 Catania, Italy

[9] Univ Cattolica Sacro Cuore, Univ Dept Life Sci & Publ Hlth, Sect Hyg, I-00168 Rome, Italy

[10] Az ULSS3 Serenissima, Dipartimento Prevenz, I-30174 Venice, Italy

[11] Az ULSS5, SIAN, Dipartimento Prevenz, I-45100 Rovigo, Italy

[12] Azienda Osped Univ Integrata Verona, I-37126 Verona, Italy

[13] Sapienza Univ Rome, Dept Publ Hlth & Infect Dis, I-00185 Rome, Italy

[14] Univ Molise, Dept Med & Hlth Sci Vincenzo Tiberio, I-86100 Campobasso, Italy

[15] Fdn Policlin Univ A Gemelli IRCCS, Dept Woman & Child Hlth & Publ Hlth, Publ Hlth Area, I-00168 Rome, Italy

来源：

JOURNAL OF PERSONALIZED MEDICINE | 2021年 / 11卷 / 02期

基金：

欧盟地平线“2020”;

关键词：

public health genomics; genetic polymorphisms; epigenetic modulations; miRNA; genetic and microbiome markers; health technology assessment; early disease prevention; HUMAN-PAPILLOMAVIRUS INFECTION; POLYGENIC RISK SCORES; ABO BLOOD-GROUP; DNA METHYLATION; PERSONALIZED MEDICINE; EPIGENETIC BIOMARKERS; SARS-COV-2; INFECTION; GUT MICROBIOTA; TECHNOLOGY-ASSESSMENT; MICRORNA EXPRESSION;

D O I：

10.3390/jpm11020135

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

The development of high-throughput omics technologies represents an unmissable opportunity for evidence-based prevention of adverse effects on human health. However, the applicability and access to multi-omics tests are limited. In Italy, this is due to the rapid increase of knowledge and the high levels of skill and economic investment initially necessary. The fields of human genetics and public health have highlighted the relevance of an implementation strategy at a national level in Italy, including integration in sanitary regulations and governance instruments. In this review, the emerging field of public health genomics is discussed, including the polygenic scores approach, epigenetic modulation, nutrigenomics, and microbiomes implications. Moreover, the Italian state of implementation is presented. The omics sciences have important implications for the prevention of both communicable and noncommunicable diseases, especially because they can be used to assess the health status during the whole course of life. An effective population health gain is possible if omics tools are implemented for each person after a preliminary assessment of effectiveness in the medium to long term.

引用

页码：1 / 30

页数：30

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