MRI patterns in prolonged low response states following traumatic brain injury in children and adolescents

被引:7
作者
Patrick, Peter D.
Mabry, Jennifer L.
Gurka, Matthew J.
Buck, Marcia L.
Boatwright, Evelyn
Blackman, James A.
机构
[1] Univ Virginia, Kluge Childrens Rehabil Ctr, Dept Pediat, Charlottesville, VA 22901 USA
[2] Univ Virginia, Inst Res, Charlottesville, VA 22901 USA
[3] Univ Virginia, Dept Publ Hlth Sci, Charlottesville, VA USA
关键词
TBI; MRI; vegetative state; coma; minimally conscious;
D O I
10.1080/02699050601111401
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Objectives: To explore the relationship between location and pattern of brain injury identified on MRI and prolonged low response state in children post-traumatic brain injury (TBI). Methods: This observational study compared 15 children who spontaneously recovered within 30 days post-TBI to 17 who remained in a prolonged low response state. Results: 92.9% of children with brain stem injury were in the low response group. The predicted probability was 0.81 for brain stem injury alone, increasing to 0.95 with a regional pattern of injury to the brain stem, basal ganglia, and thalamus. Conclusions: Low response state in children post-TBI is strongly correlated with two distinctive regions of injury: the brain stem alone, and an injury pattern to the brain stem, basal ganglia, and thalamus. This study demonstrates the need for large-scale clinical studies using MRI as a tool for outcome assessment in children and adolescents following severe TBI.
引用
收藏
页码:63 / 68
页数:6
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