Advanced Biomarkers: Therapeutic and Diagnostic Targets in Urticaria

被引：19

作者：

Zhang, Yue ^{[1
,2
]}

Zhang, Hanyi ^{[1
,2
]}

Du, Shengyi ^{[1
,2
]}

Yan, Siyu ^{[1
]}

Zeng, Jinrong ^{[1
]}

机构：

[1] Cent South Univ, Xiangya Hosp 3, Dept Dermatol, Changsha, Peoples R China

[2] Cent South Univ, Xiangya Sch Med, Changsha, Peoples R China

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 2021年 / 182卷 / 10期

关键词：

Urticaria; Biomarkers; Mast cells; Basophils; Single-nucleotide polymorphism; PLATELET-ACTIVATING-FACTOR; DIMER PLASMA-LEVELS; GENE POLYMORPHISMS; MAST-CELLS; NONSEDATING H1-ANTIHISTAMINES; BASOPHIL ACTIVATION; BLOOD-COAGULATION; DOUBLE-BLIND; VITAMIN-D; SERUM;

D O I：

10.1159/000515753

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Urticaria is a type of skin disease characterized by rapid onset of hives (superficial dermis edema, erythema, pruritus, or burning sensation). According to whether the natural course exceeds 6 weeks, urticaria can be divided into acute and chronic urticaria (CU). At present, the evaluation of CU activity mainly depends on the Urticaria Activity Score (UAS), but the evaluation indicators are relatively single, and we need more reliable experimental data for evaluation. We typically summarize advanced biomarkers and several related pathogenic pathways discovered in recent years on urticaria, including the cell adhesion/chemotaxis pathway, interleukin (IL)-6/Janus tyrosine kinase/STAT pathway, IL-17/IL-23 pathway, basophil- and mast cell-related pathway, coagulation/fibrinolysis-related pathways, single-nucleotide polymorphism, and some other pathways. This review aims to find appropriate biomarkers so that we can evaluate disease activity, discover novel therapeutic targets, and predict the patients' response more accurately to therapeutic agents.

引用

页码：917 / 931

页数：15

共 149 条

[1] IL-6 signalling pathways and the development of type 2 diabetes [J].

Akbari, Mohamad ;

Hassan-Zadeh, Vahideh .

INFLAMMOPHARMACOLOGY, 2018, 26 (03) :685-698

[2] The role of eosinophils in chronic spontaneous urticaria [J].

Altrichter, Sabine ;

Frischbutter, Stefan ;

Fok, Jie Shen ;

Kolkhir, Pavel ;

Jiao, Qingqing ;

Skov, Per Stahl ;

Metz, Martin ;

Church, Martin K. ;

Maurer, Marcus .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2020, 145 (06) :1510-1516

[3] Serial D-dimer plasma levels in a patient with chronic spontaneous urticaria developing resistance to omalizumab [J].

Asero, R. .

CLINICAL AND EXPERIMENTAL DERMATOLOGY, 2017, 42 (06) :667-669

[4] Activation of blood coagulation in plasma from chronic urticaria patients with negative autologous plasma skin test [J].

Asero, R. ;

Cugno, M. ;

Tedeschi, A. .

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2011, 25 (02) :201-205

[5]

Asero R., 2020, Eur Ann Allergy Clin Immunol, DOI 10.23822/EurAnnACI.1764

[6] Activation of the tissue factor pathway of blood coagulation in patients with chronic urticaria [J].

Asero, Riccardo ;

Tedeschi, Alberto ;

Coppola, Raffaella ;

Griffini, Samantha ;

Paparella, Paolo ;

Riboldi, Piersandro ;

Marzano, Angelo V. ;

Fanoni, Daniele ;

Cugno, Massimo .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2007, 119 (03) :705-710

[7] D-Dimer Plasma Levels Parallel the Clinical Response to Omalizumab in Patients with Severe Chronic Spontaneous Urticaria [J].

Asero, Riccardo ;

Marzano, Angelo V. ;

Ferrucci, Silvia ;

Cugno, Massimo .

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 2017, 172 (01) :40-44

[8] Heparin and Tranexamic Acid Therapy May Be Effective in Treatment-Resistant Chronic Urticaria with Elevated D-Dimer: A Pilot Study [J].

Asero, Riccardo ;

Tedeschi, Alberto ;

Cugno, Massimo .

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 2010, 152 (04) :384-389

[9] Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework [J].

Atkinson, AJ ;

Colburn, WA ;

DeGruttola, VG ;

DeMets, DL ;

Downing, GJ ;

Hoth, DF ;

Oates, JA ;

Peck, CC ;

Schooley, RT ;

Spilker, BA ;

Woodcock, J ;

Zeger, SL .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 2001, 69 (03) :89-95

[10] Serum concentration of IL-17, IL-23 and TNF-α among patients with chronic spontaneous urticaria: association with disease activity and autologous serum skin test [J].

Atwa, M. A. ;

Emara, A. S. ;

Youssef, N. ;

Bayoumy, N. M. .

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2014, 28 (04) :469-474

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