Combined photoacoustic and ultrasound biomicroscopy

被引:77
|
作者
Harrison, Tyler [1 ]
Ranasinghesagara, Janaka C. [1 ]
Lu, Huihong [1 ]
Mathewson, Kory [1 ]
Walsh, Andrew [1 ]
Zemp, Roger J. [1 ]
机构
[1] Univ Alberta, Dept Elect & Comp Engn, Edmonton, AB T6G 2V4, Canada
来源
OPTICS EXPRESS | 2009年 / 17卷 / 24期
基金
加拿大创新基金会; 加拿大自然科学与工程研究理事会;
关键词
IN-VIVO; HIGH-RESOLUTION; MICROSCOPY;
D O I
10.1364/OE.17.022041
中图分类号
O43 [光学];
学科分类号
070207 ; 0803 ;
摘要
We report on the development of an imaging system capable of combined ultrasound and photoacoustic imaging based on a fast-scanning single-element 25-MHz ultrasound transducer and a unique light-delivery system. The system is capable of 20 ultrasound frames per second and slower photoacoustic frame rates limited by laser pulse-repetition rates. Laser and ultrasound pulses are interlaced for co-registration of photoacoustic and ultrasound images. In vivo imaging of a human finger permits ultrasonic visualization of vessel structures and speckle changes indicative of blood flow, while overlaid photoacoustic images highlight some small vessels that are not clear from the ultrasound scan. Photoacoustic images provide optical absorption contrast co-registered in the structural and blood-flow context of ultrasound with high-spatial resolution and may prove important for clinical diagnostics and basic science of the microvasculature. (C) 2009 Optical Society of America
引用
收藏
页码:22041 / 22046
页数:6
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