General 5-Halomethyl Isoxazoline Synthesis Enabled by Copper-Catalyzed Oxyhalogenation of Alkenes

被引：22

作者：

Li, Xiaoqing ^{[1
]}

Ding, Yu ^{[1
]}

Qian, Lijie ^{[1
]}

Gao, Yang ^{[1
]}

Wang, Xinqiang ^{[1
]}

Yan, Xinhuan ^{[1
]}

Xu, Xiangsheng ^{[1
]}

机构：

[1] Zhejiang Univ Technol, Coll Chem Engn, Hangzhou 310014, Zhejiang, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 84卷 / 19期

关键词：

UNACTIVATED ALKENES; OXIMES; METAL;

D O I：

10.1021/acs.joc.9b02031

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A general and efficient oxyhalogenation of unsaturated ketoximes has been achieved through copper catalysis with diethyl bromomalonate, N-chlorosuccinimide, and N-iodosuccinimide, yielding 5-chloromethyl, 5-bromomethyl, and 5-iodomethyl isoxazolines in good to excellent yields.

引用

页码：12656 / 12663

页数：8

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