Enantioselective Palladium-Catalyzed Direct Arylations at Ambient Temperature: Access to Indanes with Quaternary Stereocenters

被引：152
|
作者：
Albicker, Martin R. [1 ]
Cramer, Nicolai [1 ]
机构：
[1] ETH, Organ Chem Lab, CH-8093 Zurich, Switzerland
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 48期
关键词：
asymmetric catalysis; C-H activation; direct arylation; palladium; stereocenters; H BOND FUNCTIONALIZATION; PROTON-ABSTRACTION MECHANISM; C-H; ACTIVATION; ACID; EFFICIENT;
D O I：
10.1002/anie.200905060
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Tadaa: The title reaction proceeds under essentially neutral reaction conditions at ambient temperature with a taddol-based phosphoramidite ligand L allowing the creation of indanes with quaternary stereogenic centers in high enantiomeric excess (see scheme; Tf=trifluoromethanesulfonyl, DMAc = dimethylacetamide). © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：9139 / 9142
页数：4
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