Mesenchymal Stem Cell-Based Therapy for Stroke: Current Understanding and Challenges

被引:58
作者
Li, Weifeng [1 ]
Shi, Linli [1 ,2 ]
Hu, Bei [1 ]
Hong, Yimei [1 ]
Zhang, Hao [3 ]
Li, Xin [1 ]
Zhang, Yuelin [1 ,2 ]
机构
[1] Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Dept Emergency Med, Guangzhou, Peoples R China
[2] Southern Med Univ, Sch Clin Med 2, Guangzhou, Peoples R China
[3] Bengbu Med Coll, Fac Pharm, Bengbu, Peoples R China
关键词
mesenchymal stem cell; stroke; cell therapy; mechanisms; challenges; ACUTE ISCHEMIC-STROKE; UMBILICAL-CORD BLOOD; BONE-MARROW; STROMAL CELLS; FUNCTIONAL RECOVERY; ADIPOSE-TISSUE; IN-VITRO; MITOCHONDRIAL TRANSFER; NEUROVASCULAR PLASTICITY; EXTRACELLULAR VESICLES;
D O I
10.3389/fncel.2021.628940
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Stroke, the most prevalent cerebrovascular disease, causes serious loss of neurological function and is the leading cause of morbidity and mortality worldwide. Despite advances in pharmacological and surgical therapy, treatment for functional rehabilitation following stroke is limited with a consequent serious impact on quality of life. Over the past decades, mesenchymal stem cell (MSCs)-based therapy has emerged as a novel strategy for various diseases including stroke due to their unique properties that include easy isolation, multipotent differentiation potential and strong paracrine capacity. Although MSCs have shown promising results in the treatment of stroke, there remain many challenges to overcome prior to their therapeutic application. In this review, we focus on the following issues: the scientific data from preclinical studies and clinical trials of MSCs in the treatment of stroke; the potential mechanisms underlying MSC-based therapy for stroke; the challenges related to the timing and delivery of MSCs and MSC senescence.
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页数:12
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