Prophylactic strategies to control chikungunya virus infection

被引：11

作者：

Hucke, Friederike I. L. ^{[1
]}

Bestehorn-Willmann, Malena ^{[1
]}

Bugert, Joachim J. ^{[1
]}

机构：

[1] Bundeswehr Inst Microbiol, Neuherbergstr 11, D-80937 Munich, Germany

来源：

VIRUS GENES | 2021年 / 57卷 / 02期

关键词：

CHIKV epidemiology; Antiviral design; Antiviral testing; Vaccines; Monoclonal antibodies; AEDES-ALBOPICTUS; MONOCLONAL-ANTIBODIES; GENETIC-DETERMINANTS; NONHUMAN-PRIMATES; RISK-FACTORS; VACCINE; REPLICATION; DENGUE; DISEASE; ALPHAVIRUS;

D O I：

10.1007/s11262-020-01820-x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Chikungunya virus (CHIKV) is a (re)emerging arbovirus and the causative agent of chikungunya fever. In recent years, CHIKV was responsible for a series of outbreaks, some of which had serious economic and public health impacts in the affected regions. So far, no CHIKV-specific antiviral therapy or vaccine has been approved. This review gives a brief summary on CHIKV epidemiology, spread, infection and diagnosis. It furthermore deals with the strategies against emerging diseases, drug development and the possibilities of testing antivirals against CHIKV in vitro and in vivo. With our review, we hope to provide the latest information on CHIKV, disease manifestation, as well as on the current state of CHIKV vaccine development and post-exposure therapy.

引用

页码：133 / 150

页数：18

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