Precision medicine in drug safety

被引：2

作者：

Carr, Daniel F. ^{[1
]}

Pirmohamed, Munir ^{[1
]}

机构：

[1] Univ Liverpool, Wolfson Ctr Personalised Med, MRC Ctr Drug Safety Sci, Dept Pharmacol & Therapeut, Liverpool, Merseyside, England

来源：

CURRENT OPINION IN TOXICOLOGY | 2020年 / 23-24卷

基金：

英国工程与自然科学研究理事会; 英国医学研究理事会;

关键词：

Drug safety; Precision medicine; Adverse drug reactions; Pharmacogenomics; GENOME-WIDE ASSOCIATION; INDUCED HYPERSENSITIVITY REACTIONS; TYROSINE-PHOSPHATASE PTPN22; COST-EFFECTIVENESS ANALYSIS; NEVIRAPINE HYPERSENSITIVITY; INDUCED MYELOSUPPRESSION; GENETIC-VARIATION; INDUCED MYOPATHY; JOHNSON SYNDROME; IMPLEMENTATION;

D O I：

10.1016/j.cotox.2020.07.003

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Over the past two decades, our understanding of genetic heritability has been derived from candidate gene and genome-wide studies looking at common allelic variant associations. As our access to advanced genomics technologies increases, so too does the availability of pharmacogenomic data for predicting the risk of adverse drug reactions (ADRs). We now have the ability to look at the contribution of rare and even personal genomic variants on ADR risk. However, the increase in data will be accompanied by challenges in interpretation and implementation. This review looks at the current position of drug safety pharmacogenomics and discusses the challenges, as well as some possible future directions.

引用

页码：87 / 97

页数：11

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