Teaching tumour suppressors new tricks

被引:19
作者
McCartney, BM [1 ]
Peifer, M [1 ]
机构
[1] Univ N Carolina, Dept Biol, Chapel Hill, NC 27599 USA
关键词
D O I
10.1038/35008685
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Examination of the tumour suppressor adenomatous polyposis coil (APC) has shown that it may be multifunctional. Recent work has demonstrated dynamic interactions of APC with the microtubule cytoskeleton, supporting the idea that APC has an important function in cell migration.
引用
收藏
页码:E58 / E60
页数:3
相关论文
共 20 条
[1]   NH2-terminal deletion of beta-catenin results in stable colocalization of mutant beta-catenin with adenomatous polyposis coli protein and altered MDCK cell adhesion [J].
Barth, AIM ;
Pollack, AL ;
Altschuler, Y ;
Mostov, KE ;
Nelson, WJ .
JOURNAL OF CELL BIOLOGY, 1997, 136 (03) :693-706
[2]   Mal3, the fission yeast homologue of the human APC-interacting protein EB-1 is required for microtubule integrity and the maintenance of cell form [J].
Beinhauer, JD ;
Hagan, IM ;
Hegemann, JH ;
Fleig, U .
JOURNAL OF CELL BIOLOGY, 1997, 139 (03) :717-728
[3]   The APC-associated protein EB1 associates with components of the dynactin complex and cytoplasmic dynein intermediate chain [J].
Berrueta, L ;
Tirnauer, JS ;
Schuyler, SC ;
Pellman, D ;
Bierer, BE .
CURRENT BIOLOGY, 1999, 9 (08) :425-428
[4]   The adenomatous polyposis coli-binding protein EB1 is associated with cytoplasmic and spindle microtubules [J].
Berrueta, L ;
Kraeft, SK ;
Tirnauer, JS ;
Schuyler, SC ;
Chen, LB ;
Hill, DE ;
Pellman, D ;
Bierer, BE .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (18) :10596-10601
[5]   Genetic instability in colorectal cancers [J].
Lengauer, C ;
Kinzler, KW ;
Vogelstein, B .
NATURE, 1997, 386 (6625) :623-627
[6]   Drosophila APC2 is a cytoskeletally-associated protein that regulates wingless signaling in the embryonic epidermis [J].
McCartney, BM ;
Dierick, HA ;
Kirkpatrick, C ;
Moline, MM ;
Baas, A ;
Peifer, M ;
Bejsovec, A .
JOURNAL OF CELL BIOLOGY, 1999, 146 (06) :1303-1318
[7]   Establishment of the dorsal-ventral axis in Xenopus embryos coincides with the dorsal enrichment of Dishevelled that is dependent on cortical rotation [J].
Miller, JR ;
Rowning, BA ;
Larabell, CA ;
Yang-Snyder, JA ;
Bates, RL ;
Moon, RT .
JOURNAL OF CELL BIOLOGY, 1999, 146 (02) :427-437
[8]   Adenomatous polyposis coli (APC) protein moves along microtubules and concentrates at their growing ends in epithelial cells [J].
Mimori-Kiyosue, Y ;
Shiina, N ;
Tsukita, S .
JOURNAL OF CELL BIOLOGY, 2000, 148 (03) :505-517
[9]   EB1, a protein which interacts with the APC tumour suppressor, is associated with the microtubule cytoskeleton throughout the cell cycle [J].
Morrison, EE ;
Wardleworth, BN ;
Askham, JM ;
Markham, AF ;
Meredith, DM .
ONCOGENE, 1998, 17 (26) :3471-3477
[10]  
MUHNA L, 1998, NATURE, V393, P487