Stem Cell and Idiopathic Pulmonary Fibrosis: Mechanisms and Treatment

被引：9
|
作者：
Liu, Ming [1 ]
Ren, Dunqiang [2 ]
Wu, Dong [3 ,4 ]
Zheng, Jian [5 ]
Tu, Wenwei [5 ]
机构：
[1] Guangzhou Med Univ, Affiliated Hosp 1, Guangzhou Inst Resp Dis, State Key Lab Resp Dis, Guangzhou 510120, Peoples R China
[2] Qingdao Univ, Qingdao Med Coll, Affiliated Hosp, Dept Resp Dis, Qingdao 266003, Shandong, Peoples R China
[3] Guangdong Med Coll, Affiliated Hosp, Dept Resp Dis, Zhanjiang, Peoples R China
[4] Columbia Univ, Dept Anat & Cell Biol, New York, NY USA
[5] Univ Hong Kong, Li Ka Shing Fac Med, Dept Pediat & Adolescent Med, Hong Kong 000000, Hong Kong, Peoples R China
来源：
CURRENT STEM CELL RESEARCH & THERAPY | 2015年 / 10卷 / 06期
基金：
中国国家自然科学基金;
关键词：
Embryonic stem cells; induced pluripotent stem cells; mesenchymal stem cells; pulmonary fibrosis; treatment; ACUTE LUNG INJURY; MESENCHYMAL STROMAL CELLS; MOLECULAR-MECHANISMS; CONDITIONED MEDIUM; TISSUE; AIRWAY; PATHOGENESIS; ALVEOLAR; DIFFERENTIATION; TRANSPLANTATION;
D O I：
10.2174/1574888X10666150519092639
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal lung disease resulting from multiplex causes. Evidence indicates that stem/progenitor cells might play a key role in IPF pathogenesis and repair, which may provide some novel potential strategies for the future treatment of IPF. In this review, we first summarize the current understanding of the relationship between stem cells and IPF and then review the advancements made in recent clinical trials using stem/progenitor cells, especially mesenchymal stem cells, in treating IPF and their interpretations.
引用
收藏
页码：466 / 476
页数：11
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