Highly regioselective synthesis of 1-aryl-3,4,5-substituted pyrazoles

被引：111
作者：
Gosselin, Francis
O'Shea, Paul D.
Webster, Robert A.
Reamer, Robert A.
Tillyer, Richard D.
Grabowski, Edward J. J.
机构：
[1] Merck Frosst Ctr Therapeut Res, Dept Proc Res, Kirkland, PQ H9H 3L1, Canada
[2] Merck & Co Inc, Merck Sharp & Dohme Res Labs, Dept Proc Res, Rahway, NJ 07065 USA
来源：
SYNLETT | 2006年 / 19期
关键词：
1,3-diketones; arylhydrazines; cyclocondensation; regioselectivity; amide solvents;
D O I：
10.1055/s-2006-956487
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A highly regioselective synthesis of 1-aryl-3,4,5-substituted pyrazoles based on the condensation of 1,3-diketones with arylhydrazines is described. The reaction proceeds at room temperature in N,N-dimethylacetamide and furnishes pyrazoles in 59-98% yields.
引用
收藏
页码：3267 / 3270
页数：4
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