Extracellular vesicles circulating in young organisms promote healthy longevity

被引：41

作者：

Prattichizzo, Francesco ^{[1
]}

Giuliani, Angelica ^{[2
]}

Sabbatinelli, Jacopo ^{[2
]}

Mensa, Emanuela ^{[2
]}

De Nigris, Valeria ^{[3
]}

La Sala, Lucia ^{[1
]}

de Candia, Paola ^{[1
]}

Olivieri, Fabiola ^{[2
,4
]}

Ceriello, Antonio ^{[1
]}

机构：

[1] IRCCS MultiMed, Via Fantoli 15-16, Milan, Italy

[2] Univ Politecn Marche, DISCLIMO, Dept Clin & Mol Sci, Ancona, Italy

[3] IDIBAPS, Barcelona, Spain

[4] IRCCS INRCA, Ctr Clin Pathol & Innovat Therapy, Ancona, Italy

来源：

JOURNAL OF EXTRACELLULAR VESICLES | 2019年 / 8卷 / 01期

关键词：

Extracellular vesicles; ageing; senescence; SASP; eNAMPT; NAD+; miRNAs; SIRT1; inflammaging; lifespan; physical activity; CELLS;

D O I：

10.1080/20013078.2019.1656044

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Parabiosis experiments in mice demonstrated that a young environment could partially rejuvenate multiple tissues of old organisms. However, the circulating mediators responsible of such effect have been elusive so far. Novel results suggest that extracellular vesicles isolated from plasma of young mice increase lifespan in old mice. Here we integrate these findings in a larger framework, advancing the hypothesis that circulating vesicles may mediate the beneficial effect of a young milieu on ageing.

引用

页数：4

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