Inflammation and metabolic disorders

被引：6830

作者：

Hotamisligil, Goekhan S. ^{[1
]}

机构：

[1] Harvard Univ, Sch Publ Hlth, Dept Genet & Complex Dis, Boston, MA 02115 USA

来源：

NATURE | 2006年 / 444卷 / 7121期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nature05485

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Metabolic and immune systems are among the most fundamental requirements for survival. Many metabolic and immune response pathways or nutrient- and pathogen-sensing systems have been evolutionarily conserved throughout species. As a result, immune response and metabolic regulation are highly integrated and the proper function of each is dependent on the other. This interface can be viewed as a central homeostatic mechanism, dysfunction of which can lead to a cluster of chronic metabolic disorders, particularly obesity, type 2 diabetes and cardiovascular disease. Collectively, these diseases constitute the greatest current threat to global human health and welfare.

引用

页码：860 / 867

页数：8

共 99 条

[1] The c-Jun NH2-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser307 [J].

Aguirre, V ;

Uchida, T ;

Yenush, L ;

Davis, R ;

White, MF .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (12) :9047-9054

[2]

[Anonymous], 2002, World Health Report, 2002: Reducing risks, promoting healthy life

[3] IKK-β links inflammation to obesity-induced insulin resistance [J].

Arkan, MC ;

Hevener, AL ;

Greten, FR ;

Maeda, S ;

Li, ZW ;

Long, JM ;

Wynshaw-Boris, A ;

Poli, G ;

Olefsky, J ;

Karin, M .

NATURE MEDICINE, 2005, 11 (02) :191-198

[4] Signal transduction by tumor necrosis factor and its relatives [J].

Baud, V ;

Karin, M .

TRENDS IN CELL BIOLOGY, 2001, 11 (09) :372-377

[5] Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis [J].

Baumgartl, J ;

Baudler, S ;

Scherner, M ;

Babaev, V ;

Makowski, L ;

Suttles, J ;

McDuffie, M ;

Fazio, S ;

Kahn, CR ;

Hotamisligil, GS ;

Krone, W ;

Linton, M ;

Brüning, JC .

CELL METABOLISM, 2006, 3 (04) :247-256

[6] Innate immunity: an overview [J].

Beutler, B .

MOLECULAR IMMUNOLOGY, 2004, 40 (12) :845-859

[7] Free fatty acids produce insulin resistance and activate the proinflammatory nuclear factor-κB pathway in rat liver [J].

Boden, G ;

She, PX ;

Mozzoli, M ;

Cheung, P ;

Gumireddy, K ;

Reddy, P ;

Xiang, XQ ;

Luo, ZJ ;

Ruderman, N .

DIABETES, 2005, 54 (12) :3458-3465

[8] Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network [J].

Bookout, Angie L. ;

Jeong, Yangsik ;

Downes, Michael ;

Yu, Ruth T. ;

Evans, Ronald M. ;

Mangelsdorf, David J. .

CELL, 2006, 126 (04) :789-799

[9] Biochemistry and molecular cell biology of diabetic complications [J].

Brownlee, M .

NATURE, 2001, 414 (6865) :813-820

[10] Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB [J].

Cai, DS ;

Yuan, MS ;

Frantz, DF ;

Melendez, PA ;

Hansen, L ;

Lee, J ;

Shoelson, SE .

NATURE MEDICINE, 2005, 11 (02) :183-190

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