[18F]FDG PET signal is driven by astroglial glutamate transport

被引：237

作者：

Zimmer, Eduardo R. ^{[1
,2
,3
,4
,11
]}

Parent, Maxime J. ^{[1
,2
,3
]}

Souza, Debora G. ^{[4
,10
]}

Leuzy, Antoine ^{[1
,2
,3
,12
]}

Lecrux, Clotilde ^{[5
]}

Kim, Hyoung-Ihl ^{[6
,7
,8
]}

Gauthier, Serge ^{[1
,2
,3
]}

Pellerin, Luc ^{[10
]}

Hamel, Edith

Rosa-Neto, Pedro ^{[1
,2
,3
,9
]}

机构：

[1] McGill Univ, TNL, MCSA, Douglas Mental Hlth Univ Inst,Dept Neurol & Neuro, Montreal, PQ, Canada

[2] McGill Univ, Dept Psychiat, Montreal, PQ, Canada

[3] McGill Univ, Dept Pharmacol, Montreal, PQ, Canada

[4] Univ Fed Rio Grande do Sul, Dept Biochem, Porto Alegre, RS, Brazil

[5] McGill Univ, Montreal Neurol Inst, Lab Cerebrovasc Res, Montreal, PQ, Canada

[6] Gwangju Inst Sci & Technol, Dept Med Syst Engn, Gwangju, South Korea

[7] Gwangju Inst Sci & Technol, Sch Mechatron, Gwangju, South Korea

[8] Presbyterian Med Ctr, Dept Neurosurg, Jeonju, South Korea

[9] McGill Univ, Montreal Neurol Inst, McConnell Brain Imaging Ctr, Montreal, PQ, Canada

[10] Univ Lausanne, Dept Physiol, Lausanne, Switzerland

[11] Pontificia Univ Catolica Rio Grande do Sul, Brain Inst Rio Grande do Sul BraIns, Porto Alegre, RS, Brazil

[12] Karolinska Inst, Div Translat Alzheimers Neurobiol, Dept Neurobiol Care Sci & Soc, Ctr Alzheimers Res, Stockholm, Sweden

来源：

NATURE NEUROSCIENCE | 2017年 / 20卷 / 03期

基金：

新加坡国家研究基金会; 加拿大健康研究院;

关键词：

POSITRON-EMISSION-TOMOGRAPHY; ALZHEIMERS-DISEASE; ENERGY-METABOLISM; ASTROCYTES; BRAIN; EXPRESSION; NEURONS; MODEL;

D O I：

10.1038/nn.4492

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Contributions of glial cells to neuroenergetics have been the focus of extensive debate. Here we provide positron emission tomography evidence that activation of astrocytic glutamate transport via the excitatory amino acid transporter GLT-1 triggers widespread but graded glucose uptake in the rodent brain. Our results highlight the need for a reevaluation of the interpretation of [F-18]FDG positron emission tomography data, whereby astrocytes would be recognized as contributing to the [F-18]FDG signal.

引用

页码：393 / 395

页数：3

共 20 条

[1] Abnormal metabolic connectivity in the pilocarpine-induced epilepsy rat model: A multiscale network analysis based on persistent homology [J].