Neurobiological underpinnings and modulating factors in schizophrenia spectrum disorders with a comorbid substance use disorder: A systematic review

被引:20
作者
Adan, Ana [1 ,2 ]
Arredondo, Arantxa Y. [1 ]
del Mar Capella, Maria [1 ]
Prat, Gemma [1 ]
Forero, Diego A. [3 ]
Francisco Navarro, Jose [4 ]
机构
[1] Univ Barcelona, Sch Psychol, Dept Clin Psychol & Psychobiol, Passeig Vall dHebron 171, Barcelona 08035, Spain
[2] Univ Barcelona, Inst Neurosci, Passeig Vall dHebron 171, Barcelona 08035, Spain
[3] Univ Antonio Narino, Sede Circunvalar, Sch Med, Lab NeuroPsychiat Genet,Biomed Sci Res Grp, Bogota 110231, Colombia
[4] Univ Malaga, Sch Psychol, Dept Psychobiol, Campus Teatinos S-N, E-29071 Malaga, Spain
关键词
Schizophrenia spectrum disorders; Substance use disorders; Comorbidity; Dual schizophrenia spectrum disorders; Schizophrenia; Neuroimaging; Illness duration; BRAIN VOLUME DEFICITS; GREY-MATTER DEFICITS; CANNABIS USE; WHITE-MATTER; 1ST-EPISODE SCHIZOPHRENIA; ANTIPSYCHOTIC MEDICATION; DUAL DIAGNOSIS; ALCOHOL-USE; ABUSE; HIPPOCAMPAL;
D O I
10.1016/j.neubiorev.2017.01.038
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Recently there is a growing interest in the interaction of schizophrenia spectrum disorders (SSD) and substance use disorders (SUD), a condition named dual schizophrenia spectrum disorders (SSD+). While previous research has focused on clinical and cognitive aspects, little is known about the impact of comorbidity in the brain structure and functions. Evidence suggests that dual diagnosis patients, including SSD+, show a better neurocognitive functioning during the first years of illness, followed by a serious long-term decline. The initial search retrieved 94 articles, 12 were excluded for being redundant and 49 for not fulfilling the selection criteria. Thirty-three structural and functional neuroimaging studies that compare SSD and SSD+ patients were included. Both groups exhibited more brain alterations, in comparison to only SUD patients and healthy controls. SSD+ patients are less cognitively and emotionally impaired than non-dual SSD, but worse than healthy controls. The neurobiological alterations are prominent in SSD+ after five years of illness or longer. Moreover, SUD characteristics are important modulating factors, contrary to clinical severity or specific SSD diagnosis. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码:361 / 377
页数:17
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