The Prodrug Approach: A Successful Tool for Improving Drug Solubility

被引：202
作者：
Jornada, Daniela Hartmann [1 ]
dos Santos Fernandes, Guilherme Felipe [1 ]
Chiba, Diego Eidy [1 ]
Ferreira de Melo, Thais Regina [1 ]
dos Santos, Jean Leandro [1 ]
Chung, Man Chin [1 ]
机构：
[1] Univ Estadual Paulista, UNESP, Fac Ciencias Farmaceut, Rodovia Araraquara Jau Km 01, BR-14801902 Araraquara, SP, Brazil
来源：
MOLECULES | 2016年 / 21卷 / 01期
基金：
巴西圣保罗研究基金会;
关键词：
prodrug; solubility; water-soluble prodrugs; solubility of prodrugs; molecular modification; WATER-SOLUBLE PRODRUGS; ADENOSINE RECEPTOR ANTAGONISTS; HISTONE DEACETYLASE INHIBITORS; IN-VIVO EVALUATION; PALM OIL; ANTISTAPHYLOCOCCAL EFFICACY; ESLICARBAZEPINE ACETATE; BIOLOGICAL-ACTIVITY; GAMMA-TOCOTRIENOL; TOPOISOMERASE-IV;
D O I：
10.3390/molecules21010042
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Prodrug design is a widely known molecular modification strategy that aims to optimize the physicochemical and pharmacological properties of drugs to improve their solubility and pharmacokinetic features and decrease their toxicity. A lack of solubility is one of the main obstacles to drug development. This review aims to describe recent advances in the improvement of solubility via the prodrug approach. The main chemical carriers and examples of successful strategies will be discussed, highlighting the advances of this field in the last ten years.
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页数：31
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