Prognostic importance of plasma C-reactive protein (CRP) in oncology

被引:30
作者
Daniel, Deme [1 ]
Andras, Telekes [1 ,2 ]
机构
[1] Szent Lazar Megyei Korhaz, Onkol Osztaly, Salgotarjan, Hungary
[2] Bajcsy Zsilinszky Korhaz, Onkol Osztaly, Budapest, Hungary
关键词
C-reactive protein; prognostic factor; malignant diseases; SQUAMOUS-CELL CARCINOMA; GASTRIC-CANCER; CLINICAL-SIGNIFICANCE; POOR-PROGNOSIS; LUNG-CANCER; CARCINOEMBRYONIC ANTIGEN; ESOPHAGEAL-CARCINOMA; TUMOR-MARKERS; LARGE COHORT; SERUM-LEVELS;
D O I
10.1556/650.2017.30646
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Chronic inflammation has a key role in the pathogenesis of malignancy. C-reactive protein (CRP) is produced due to the induction of inflammatory cytokines primarily in hepatocytes. In case of malignant diseases CRP might be elevated without any other condition of inflammation. Thus in the literature the authors searched for correlation between CRP levels and the course of malignant diseases. Normal CRP level measured at baseline correlates with longer overall survival in early staged malignancies. Lower CRP level at baseline predicts better prognosis in locally advanced or metastatic stages. Based on the available data, baseline CRP might be a prognostic factor in oncological diseases. Further prospective studies are warranted in various locally advanced and metastatic malignancies to clarify a possible prognostic and predictive role of CRP.
引用
收藏
页码:243 / 256
页数:14
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