The relevance of pre-motor symptoms in Parkinson's disease

被引：30

作者：

Visanji, Naomi ^{[1
]}

Marras, Connie ^{[1
]}

机构：

[1] Toronto Western Hosp, Morton & Gloria Shulman Movement Disorders Ctr, 399 Bathurst St, Toronto, ON M5T 2S8, Canada

来源：

EXPERT REVIEW OF NEUROTHERAPEUTICS | 2015年 / 15卷 / 10期

关键词：

alpha synuclein; autonomic dysfunction; constipation; depression; excessive daytime sleepiness; olfactory dysfunction; Parkinson's disease; pre-motor; rem behaviour disorder; SLEEP BEHAVIOR DISORDER; CARDIAC SYMPATHETIC DENERVATION; EXCESSIVE DAYTIME SLEEPINESS; BULB ALPHA-SYNUCLEINOPATHY; MILD COGNITIVE IMPAIRMENT; BOWEL MOVEMENT FREQUENCY; QUALITY-OF-LIFE; OLFACTORY DYSFUNCTION; NONMOTOR SYMPTOMS; MYOCARDIAL SCINTIGRAPHY;

D O I：

10.1586/14737175.2015.1083423

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Parkinson's disease (PD) has a wide range of non-motor symptoms including; constipation, sleep disturbance, deficits in vision and olfaction, mood disorders and cardiac autonomic dysfunction. Several of these non-motor symptoms can manifest prior to the onset of motor symptoms. Recognizing these pre-motor symptoms may enable early diagnosis of PD. Currently, no single pre-motor symptom is able to predict the development of PD with 100% sensitivity or specificity. Ongoing studies in several independent at-risk cohorts should reveal the potential of combinations of pre-motor symptoms and multi-stage screening strategies to identify individuals at increased risk of PD. PD progression may be governed by a prion-like spread of a-syn throughout the nervous system. Identifying individuals at the earliest stage will likely be critical to preventing the pathological progression of PD, highlighting the relevance of pre-motor symptoms in the future treatment of the disease.

引用

页码：1205 / 1217

页数：13

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