A new efficient chiral iridium catalyst for asymmetric transfer hydrogenation of ketones

被引：37

作者：

Li, YY ^{[1
]}

Zhang, H ^{[1
]}

Chen, JS ^{[1
]}

Liao, XL ^{[1
]}

Dong, ZR ^{[1
]}

Gao, JX ^{[1
]}

机构：

[1] Xiamen Univ, Dept Chem, State Key Lab Phys Chem Solid Surface, Xiamen 361005, Peoples R China

来源：

JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL | 2004年 / 218卷 / 02期

关键词：

chiral ligand; chiral iridium complex; asymmetric transfer hydrogenation; aromatic ketone; chiral alcohol;

D O I：

10.1016/j.molcata.2004.04.020

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The interaction of [Ir(COD)Cl](2) with chiral tetradentate diaminodiphosphine ligands gave chiral diaminodiphosphine-Ir(I) complexes, which were characterized by IR, NMR and CD. The new chiral iridium(l) complex catalysts were applied to asymmetric transfer hydrogenation of various aromatic ketones using 2-propanol as a source of hydrogen. The results showed that the corresponding chiral alcohols could be obtained with high activity (up to 99.4% yield) and excellent enantioselectivities (up to 99.0% ee) under mild conditions. Propiophenone was a preferred substrate with respect to catalytic activity and enantioselectivity in the presence of base. The catalytic turnover reached 4780 mol product/mol iridium and the turnover frequency was as high as 1593 h(-1) at 55degreesC. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：153 / 156

页数：4

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