Synthesis of substituted 5-aminobenzothieno[3,2-c]isoquinolines and their sulfinyl and sulfonyl derivatives

被引：6

作者：

Kalugin, V. E. ^{[1
]}

Shestopalov, A. M. ^{[1
]}

机构：

[1] Russian Acad Sci, ND Zelinskii Organ Chem Inst, Moscow 119991, Russia

来源：

RUSSIAN CHEMICAL BULLETIN | 2015年 / 64卷 / 04期

关键词：

2-mercaptobenzonitriles; 2-(chloromethyl)benzonitrile; potassium tert-butoxide; domino reaction 5-aminobenzothieno[3,2-c]isoquinolines; 5-aminobenzothieno[3,2-c]isoquinoline 11-oxides; 5-aminobenzothieno[3,2-c]isoquinoline 11,11-dioxides; INHIBITORS;

D O I：

10.1007/s11172-015-0948-9

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A method for the preparation of substituted 5-aminobenzothieno[3,2-c]isoquinolines in good yields by the condensation of substituted 2-mercaptobenzonitriles with 2-(chloromethyl)benzonitrile and a subsequent treatment of the condensation products with potassium tert-butoxide was suggested. The oxidation of the condensation products to sulfoxides or sulfones and a subsequent treatment of these compounds with potassium tert-butoxide led to the preparation of substituted 5-aminobenzothieno[3,2-c]isoquinoline 11-oxides or 5-aminobenzothieno[3,2-c]isoquinoline 11,11-dioxides in good yields.

引用

页码：878 / 882

页数：5

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