Expression patterns of antioxidant genes in human SH-SY5Y cells after treatment with methadone

被引：19

作者：

Saify, Khyber ^{[1
]}

Saadat, Mostafa ^{[1
]}

机构：

[1] Shiraz Univ, Dept Biol, Coll Sci, Shiraz, Iran

来源：

PSYCHIATRY RESEARCH | 2015年 / 230卷 / 01期

关键词：

Antioxidant; Gene expression; Methadone; MAINTENANCE TREATMENT; REACTIVE OXYGEN; SUSCEPTIBILITY; ASSOCIATION; PREVALENCE; ENZYMES; HEROIN; GSTM1; GSTT1; SP1;

D O I：

10.1016/j.psychres.2015.08.027

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

The expression levels of nine antioxidant genes in SH-SY5Y cells exposed to methadone (final concentrations 1-20 mu M) were investigated. Based on this study the genes could be categorized on three different groups. The number of down-regulated genes were increased as a function of exposure time (P=0.004). The methadone associated mRNA alterations were modulated by N-acetyl-cysteine. These findings suggested that different pathways for regulation of antioxidant genes could be active after exposing of SH-SY5Y cells to methadone; and also suggested that methadone might act by inducing the reactive oxygen species. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

引用

收藏

页码：116 / 119

页数：4

相关论文

共 19 条

[1] Prevalence of psychiatric disorder in a methadone maintenance population [J].

Callaly, T ;

Trauer, T ;

Munro, L ;

Whelan, G .

AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY, 2001, 35 (05) :601-605

[2] Prevalence of psychiatric disorders among heroin users who received methadone maintenance therapy in Taiwan [J].

Fan, Chiung-Yueh ;

Tan, Happy Kuy-Lok ;

Chien, I-Chia ;

Chou, Sun-Yuan .

AMERICAN JOURNAL ON ADDICTIONS, 2014, 23 (03) :249-256

[3] Methadone maintenance and cancer risk: An Israeli case registry study [J].

Grinshpoon, Alexander ;

Barchana, Micha ;

Lipshitz, Irena ;

Rosca, Paula ;

Weizman, Abraham ;

Ponizovsky, Alexander M. .

DRUG AND ALCOHOL DEPENDENCE, 2011, 119 (1-2) :88-92

[4] Association between null alleles of GSTM1 and GSTT1 and dependence to heroin and opium [J].

Khalighinasab, Mohammad Rashid ;

Saify, Khyber ;

Saadat, Mostafa .

PSYCHIATRY RESEARCH, 2015, 228 (03) :977-978

[5]

Khalighinasab MR, 2015, MOL BIOL RES COMMUN, V4, P25

[6] μ-Opioid receptor-stimulated synthesis of reactive oxygen species is mediated via phospholipase D2 [J].

Koch, Thomas ;

Seifert, Anja ;

Wu, Dai-Fei ;

Rankovic, Marija ;

Kraus, Juergen ;

Boerner, Christine ;

Brandenburg, Lars-Ove ;

Schroeder, Helmut ;

Hoellt, Volker .

JOURNAL OF NEUROCHEMISTRY, 2009, 110 (04) :1288-1296

[7] Effect of amphetamine on corrected-QT interval change during methadone maintenance treatment in Taiwan: A prospective cohort study [J].

Lin, Ni-Chi ;

Huang, Chieh-Liang ;

Chen, Chung-Ying ;

Lin, Tsang-Yaw ;

Wang, Hsiu-Yi ;

Lu, Ye-Hsu ;

Chen, Lin-Mei ;

Chen, Vincent Chin-Hung ;

Gossop, Michael .

DRUG AND ALCOHOL REVIEW, 2014, 33 (02) :194-201

[8] Cytochrome P450 2D6 enzyme neuroprotects against 1-methyl-4-phenylpyridinium toxicity in SH-SY5Y neuronal cells [J].

Mann, Amandeep ;

Tyndale, Rachel F. .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2010, 31 (07) :1185-1193

[9]

Mohammadynejad P., 2011, BIPOLAR DISORDER POL

[10] Corrected-QT intervals as related to methadone dose and serum level in methadone maintenance treatment (MMT) patients - a cross-sectional study [J].

Peles, Einat ;

Bodner, Gershon ;

Kreek, Mary Jeanne ;

Rados, Vera ;

Adelson, Miriam .

ADDICTION, 2007, 102 (02) :289-300