A modified approach to 2-(N-aryl)-1,3-oxazoles:: Application to the synthesis of the IMPDH inhibitor BMS-337197 and analogues

被引：37

作者：

Dhar, TGM ^{[1
]}

Guo, JQ ^{[1
]}

Shen, ZQ ^{[1
]}

Pitts, WJ ^{[1
]}

Gu, HH ^{[1
]}

Chen, BC ^{[1
]}

Zhao, RL ^{[1
]}

Bednarz, MS ^{[1
]}

Iwanowicz, EJ ^{[1
]}

机构：

[1] Bristol Myers Squibb Co, Pharmaceut Res Inst, Princeton, NJ 08543 USA

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 12期

关键词：

D O I：

10.1021/ol020073i

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHIC] A modified approach to the synthesis of 2-(N-aryl)-1,3-oxazoles, employing an optimized iminophosphorane/heterocumulene-mediated methodology, and its application to the synthesis of BMS-337197, a potent inhibitor of IMPDH, are described.

引用

页码：2091 / 2093

页数：3

共 7 条

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