Nanosized Micelles Self-Assembled from amphiphilic dextran-graft-methoxypolyethylene glycol/poly(ε-caprolactone) copolymers

A series of amphiphilic copolymers, dextran-graft-methoxypolyethylene glycol/poly(epsilon-caprolactone) (Dex-g-mPEG/PCL) were synthesized by grafting both PCL and mPEG chains to dextran, and subsequently the micellar self-assembly behavior of resultant copolymers was investigated. PCL was designed by using Fmoc-protected valine other than organometallic catalyst as the initiator to ring-opening polymerize E-caprolactone (CL) in view of the safety demand as well as the extra application potential resulting from -NH2 group introduced after Fmoc deprotection. All the copolymers were characterized by H-1 NMR, FT-IR and GPC measurements. The prepared copolymers are capable of self-assembling into nanosized spherical micelles in aqueous solution with the diameter of around 100200 nm determined by TEM image and DLS measurement. The critical micellar concentration (CIVIC) of the graft copolymers is in the range of 10-100 mg/L determined by the fluorescence robe technique using pyrene. The result also indicated that the CIVIC of self-assembled micelles could be adjusted by controlling the degree of substitution of mPEG and PCL, and these micelles may find great potential as drug carriers in biomedical fields. (C) 2008 Elsevier Ltd. All rights reserved.