Tetrakis(1-3-diazinane-2-thione)platinum(II) chloride monohydrate complex: Synthesis, spectroscopic characterization, crystal structure and in vitro cytotoxic activity against A549, MCF7, HCT15 and HeLa human cancer lines

被引：17

作者：

Mustafa, A. Zainelabdeen A. ^{[1
]}

Altaf, Muhammad ^{[1
]}

Monim-ul-Mehboob, M. ^{[1
]}

Fettouhi, Mohammed ^{[1
]}

Wazeer, Mohammed I. M. ^{[1
]}

Isab, Anvarhusein A. ^{[1
]}

Dhuna, Vikram ^{[2
]}

Bhatia, Gaurav ^{[2
]}

Dhuna, Kshitija ^{[3
]}

机构：

[1] King Fand Univ Petr & Minerals, Dept Chem, Dhahran 31261, Saudi Arabia

[2] DAV Coll, Dept Biotechnol, Amritsar 143001, Punjab, India

[3] Guru Nanak Dev Univ, Dept Mol Biol & Biochem, Amritsar 143005, Punjab, India

来源：

INORGANIC CHEMISTRY COMMUNICATIONS | 2014年 / 44卷

关键词：

Dichloridotetrakis(1,3-diazinane-2-thione); platinum(II) complex; Single crystal X-ray structure; Pt-195; NMR; In vitro cytotoxicity studies; PLATINUM(II) COMPLEXES; CISPLATIN; C-13; DERIVATIVES; ANTIFUNGAL; THIOUREA; THIONES; DRUGS; N-15; H-1;

D O I：

10.1016/j.inoche.2014.03.020

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

This communication reports on the synthesis, crystal structure and anticancer activities of a new Pt(II) complex [Pt(Diaz)(4)]Cl-2 center dot H2O of a heterocyclic thione, where Diaz = 1,3-diazinane-2-thione. Solid state Pt-195, N-15 and C-13 NMR are also reported along with other spectroscopic data. The cytotoxic evaluation of the complex against A549, MCF7, HCT15 and HeLa human cancer lines is reported. The title compound was found to be a better cytotoxic agent against MCF7 than cisplatin. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：159 / 163

页数：5

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