Thio analogs of pyrimidine bases: Syntheses and EIMS studies of new 2-(and 4-) O-(M- and P-) halobenzylthio-6-methyluracils

被引：5

作者：

Wyrzykiewicz, E

Nowakowska, Z

机构：

[1] Faculty of Chemistry, Adam Mickiewicz University, 60-780 Poznań

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 1996年 / 118卷

关键词：

2-; and; 4-benzylthio-6-methyluracils; ortho-(meta- and para-)halobenzyl halides; EIMS; structural isomers;

D O I：

10.1080/10426509608038813

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Twelve new oltho-, meta- and para- chloro-(and bromo)-substituted derivatives of 2- and 4-benzylthio-6-methyluracils have been prepared in the reactions of 2- and 4-thio-6-methyluracil with the corresponding benzyl halides. Fl induced mass spectral fragmentation of these compounds was investigated. Fragmentation pathways are proposed on the basis of accurate mass and metastable transitions measurements. The correlation between the abundance of the M+. and the selected fragment ions of the investigated compounds is discussed. The data obtained create the basis for distinguishing structural isomers.

引用

页码：205 / 217

页数：13

共 42 条

[1] Thio Analogs of Pyrimidine Bases: Synthesis And Spectroscopic Study of New Potentially Biologically Active Disulfides of N,O-(N,N- or O,O-)-Di- and N,N,O-Tri-(o-, m-, and p-)bromobenzyl-2-thiouracils
Pospieszny, Tomasz
Wyrzykiewicz, Elzbieta
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2010, 185 (10) : 2101 - 2107
[2] Thio analogs of pyrimidine bases:: Syntheses, EIMS and 13C NMR study of new ortho-(meta- and para-) substituted derivatives of 2-benzylthio-5-bromo-6-methyluracils
Wyrzykiewicz, E
Mielcarek, S
Migon, A
Badura, J
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2002, 177 (04) : 811 - 823
[3] Electron impact mass spectral study of 1,2-di-o-(m- and p-)nitro-(bromo-)benzyl-2-thio-6-methyluracils and 1,2-di-o-(m- and p-)nitro-(bromo-)benzyl-2-thio-5-bromo-6-methyluracils
Wyrzykiewicz, E
Pospieszny, T
Bartóg, A
RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2005, 19 (04) : 580 - 584
[4] MASS-SPECTROMETRY OF THIO ANALOGS OF PYRIMIDINE-BASES - 2-(E) AND 4-(E)-STILBENYLOXYALKYLTHIOURACILS
WYRZYKIEWICZ, E
WYBIERALSKA, J
GRZESIAK, J
PRUKALA, W
ORGANIC MASS SPECTROMETRY, 1989, 24 (12): : 1072 - 1074
[5] Gas Chromatography Electron Ionization Mass Spectral Analysis of Thio Analogues of Pyrimidine Bases: 5-Bromo-2,4-di-o-(m- and p-)chloro-(bromo-)benzylthiouracils and 6-methyluracils
Bartkowiak, G.
Wyrzykiewicz, E.
Schroeder, G.
INTERNATIONAL JOURNAL OF SPECTROSCOPY, 2012,
[6] MASS-SPECTROMETRY OF THIO ANALOGS OF PYRIMIDINE-BASES - CORRELATION OF THE INTENSITIES OF THE M(+) AND SELECTED FRAGMENT IONS OF O-(M--AND-P-) SUBSTITUTED BENZYLTHIOURACILS
WYRZYKIEWICZ, E
NOWAKOWSKA, Z
JOURNAL OF MASS SPECTROMETRY, 1995, 30 (02): : 269 - 274
[7] Formation and decomposition of distonic o-, m-, and p-benzyne radical cations from photolysis of Mg+(o-, m-, p-C6H4F2)
Liu, HC
Wang, CS
Guo, W
Wu, YD
Yang, SH
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (14) : 3794 - 3798
[8] Studies in the coumaranone series Part I The Preparation of 4-, 5-, and 6-methylcoumaranones-2-ones, and some derivatives of o-, m-, and p-tolyloxyacetic acids
Higginbotham, L
Stephen, H
JOURNAL OF THE CHEMICAL SOCIETY, 1920, 117 : 1534 - 1542
[9] A New Approach to the Efficient Method for the Asymmetric Synthesis of (S)-O-, M-, P-Fluorophenylalanines and Their 2-Methyl-substituted Analogs
Saghiyan, Ashot S.
Petrosyan, Satenik G.
Manasyan, Luiza L.
Dadayan, Slavik A.
Geolchanyan, Arpine V.
Panosyan, Henry A.
Maleev, Victor I.
Khrustalev, Victor N.
SYNTHETIC COMMUNICATIONS, 2011, 41 (04) : 493 - 506
[10] Thio analogs of pyrimidine bases:: Syntheses and EIMS study of new ortho-(meta- and para-)bromobenzyl S-mono and S-N-1-disubstituted 5-morpholinomethyl(5-piperidinomethyl)-2-thiouracils
Wyrzykiewicz, Elzbieta
Pospieszny, Tomasz
JOURNAL OF HETEROCYCLIC CHEMISTRY, 2007, 44 (01) : 55 - 61

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