Interleukin receptor-associated kinase (IRAK-4) deficiency associated with bacterial infections and failure to sustain antibody responses

被引：66

作者：

Day, N

Tangsinmankong, N

Ochs, H

Rucker, R

Picard, C

Casanova, JL

Haraguchi, S

Good, R

机构：

[1] Univ S Florida, Div Allergy & Immunol, Dept Pediat, St Petersburg, FL 33620 USA

[2] All Childrens Hosp, St Petersburg, FL USA

[3] Univ Washington, Sch Med, Div Immunol Infect Dis & Rheumatol, Dept Pediat, Seattle, WA USA

[4] Univ Paris 05, INSERM, U550, Fac Necker,Lab Genet Humaine Malad Infect, Paris, France

来源：

JOURNAL OF PEDIATRICS | 2004年 / 144卷 / 04期

关键词：

D O I：

10.1016/j.jpeds.2003.11.025

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

We previously described a girl with recurrent episodes of pneumococcal pneumonia with septicemia and other infections,(1) ;found to have interleukin-1 receptor-associated kinase 4 deficiency (IRAK-4) deficieney.(2) In this report, we show that our patient is unable to sustain antibody responses either to polysaccharide or protein antigens or to a neoantigen-bacteriophage.

引用

页码：524 / 526

页数：3

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