Efficient Hit and Lead Compound Evaluation Strategy Based on Off-Rate Screening by Surface Plasmon Resonance

被引：13

作者：

Liu, Liu ^{[1
,2
]}

机构：

[1] Univ Michigan, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Internal Med, Ann Arbor, MI 48109 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2014年 / 57卷 / 07期

关键词：

DRUG DISCOVERY; INHIBITORS; DESIGN;

D O I：

10.1021/jm5003815

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The time-consuming and labor intensive compound separation and purification process before they can be evaluated have been the bottleneck steps of novel drug discovery. A new screening strategy that can evaluate crude reaction mixtures without separation and purification by determining dissociation rate constants of compounds in crude reaction mixtures was developed and validated by scientists from the Vernalis. This new strategy will significantly improve the efficiency of early stages in drug discovery.

引用

页码：2843 / 2844

页数：2

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