Fluorinated Polyurethane Scaffolds for 19F Magnetic Resonance Imaging

被引：17

作者：

Lammers, Twan ^{[1
,2
]}

Mertens, Marianne E. ^{[1
]}

Schuster, Philipp ^{[3
,4
]}

Rahimi, Khosrow ^{[5
]}

Shi, Yang ^{[1
]}

Schulz, Volkmar ^{[1
]}

Kuehne, Alexander J. C. ^{[5
]}

Jockenhoevel, Stefan ^{[3
,4
]}

Kiessling, Fabian ^{[1
]}

机构：

[1] RWTH Aachen Univ Clin, Inst Expt Mol Imaging, Pauwelsstr 30, D-52074 Aachen, Germany

[2] Univ Twente, Dept Targeted Therapeut, POB 217, NL-7500 AE Enschede, Netherlands

[3] Rhein Westfal TH Aachen, AME Helmholtz Inst Biomed Engn, Dept Biohybrid & Med Text, Pauwelsstr 20, D-52074 Aachen, Germany

[4] Rhein Westfal TH Aachen, ITA Inst Text Technol, Pauwelsstr 20, D-52074 Aachen, Germany

[5] DWI Leibniz Inst Interact Mat, Forckenbeckstr 50, D-52074 Aachen, Germany

来源：

CHEMISTRY OF MATERIALS | 2017年 / 29卷 / 07期

基金：

欧洲研究理事会;

关键词：

DETECT PROTEASE ACTIVITY; CELLULAR THERAPEUTICS; MRI; PROBE; DESIGN;

D O I：

10.1021/acs.chemmater.6b04649

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Researchers used fluorinated polyurethane scaffolds for 19F magnetic resonance imaging. They generated a novel fluorinated polymer based on thermoplastic polyurethane (19F -TPU) which possesses distinct properties rendering it suitable for fluorine-based MRI. The 19F -TPU is synthesized from a perfluorinated aromatic diisocyanate and butanediol. After polymerization, the polyurethane is N-alkylated to obtain a noncrystalline material with partially fluorinated alkyl side chains. To provide proof-of-principle for the usefulness of 19F -TPU for developing MRI-detectable scaffold materials, it was processed into monofilaments via melt spinning.

引用

页码：2669 / 2671

页数：3

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