An unusual cause of food-induced anaphylaxis in mothers

被引：9

作者：

Soh, J. Y. ^{[1
,2
]}

Chiang, W. C. ^{[3
]}

Huang, C. H. ^{[1
,2
]}

Woo, C. K. ^{[4
]}

Ibrahim, I. ^{[5
,6
]}

Heng, K. ^{[6
,7
]}

Pramanick, A. ^{[8
]}

Lee, B. W. ^{[1
,2
]}

机构：

[1] Natl Univ Singapore Hosp, Dept Paediat, Tower Block Level 12,1E Kent Ridge Rd, Singapore 119228, Singapore

[2] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Paediat, Singapore, Singapore

[3] Kandang Kerbau Womens & Childrens Hosp, Dept Paediat, Singapore, Singapore

[4] Gleneagles Hosp Kuala Lumpur, Dept Med, Kuala Lumpur, Malaysia

[5] Natl Univ Hlth Syst, Natl Univ Hosp, Emergency Med Dept, Singapore, Singapore

[6] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Surg, Singapore, Singapore

[7] Tan Tock Seng Hosp, Emergency Dept, Singapore, Singapore

[8] Kandang Kerbau Womens & Childrens Hosp, Dept Obstet & Gynaecol, Singapore, Singapore

来源：

WORLD ALLERGY ORGANIZATION JOURNAL | 2017年 / 10卷

基金：

英国医学研究理事会;

关键词：

Anaphylaxis; Pregnancy; Galacto-Oligosaccharide; ALPHA-GAL; NONDIGESTIBLE OLIGOSACCHARIDES; PREGNANCY; FRUCTOOLIGOSACCHARIDE; SUPPLEMENTATION; SENSITIZATION; FORMULA; ALLERGY; MICE; TERM;

D O I：

10.1186/s40413-016-0136-x

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Background: Galacto-oligosaccharides (GOS) are prebiotics added to commercial milk formula of infants and mothers. In recent years, cases of allergy related to GOS in atopic children have been reported in the South East Asian region. Case presentations: We describe a series of pregnant (n = 4) and lactating mothers (n = 2) who developed anaphylactic reactions after consumption of maternal milk formula containing GOS. All six subjects had preexisting atopy and a positive skin prick test to GOS and 5/5 of the subjects who were tested had positive basophil activation tests to GOS. All of the mothers and their babies had normal neonatal outcomes after the reactions. Conclusions: The supplementation of GOS into milk and beverages in the Asian region should take into account the rare chance of allergenicity of GOS in the atopic population.

引用

页数：5

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