Serum Phosphate, Serum Calcium and Serum iPTH Levels in Patients with CKD and Risk of Cardiovascular events

Objective: To determine the association between serum phosphorus, serum calcium, and serum iPTH and the occurrence of cardiovascular events in patients with diagnosed chronic kidney disease. Methodology: A prospective cohort study was conducted at Pir Abdul Qadir Shah Jeelani Institute Of Medical Sciences Gambat, Khairpur Mirs and Jinnah Postgraduate Medical Centre between August 2019 and July 2020. All patients over 18 years of age were eligible to participate in the study. Patients with incomplete data or those who were lost to follow-up were excluded from the study. Mineral metabolism parameters including, serum calcium, Phosphorus, and intact iPTH (iPTH), levels were recorded for all patients. Patients were followed up till the start of August 2020 to record any cardiovascular event. Patients were sub stratified into two groups i.e. with or without a CV event. Results: The study reported that with the exception of serum calcium, both iPTH and serum phosphorus were significantly associated with occurrence of CV events. iPTH levels had a direct association with CV events with a mean iPTH of 157.34 +/- 106.95 pg/ml in patients with CV events versus 108.98 +/- 85.63 pg/ml in patients without any CV event (P=0.0005). The mean serum phosphorus for the group with CV event was 3.57 +/- 0.73 mg/dl which was significantly higher than those without CV events (P=0.03). Conclusion: The current study indicated that serum phosphorus and intact iPTH levels were significantly associated with CV events in patients with CKD.