Characterization, antibacterial, antioxidant, antidiabetic, anti-inflammatory and antityrosinase activity of green synthesized silver nanoparticles using Calophyllum tomentosum leaves extract

被引:165
|
作者
Govindappa, M. [1 ]
Hemashekhar, B. [2 ]
Arthikala, Manoj-Kumar [3 ]
Ravishankar Rai, V [4 ]
Ramachandra, Y. L. [5 ]
机构
[1] Dayananda Sagar Coll Engn, Dept Biotechnol, Shavige Malleshwara Hills, Bengaluru 560078, Karnataka, India
[2] Shridevi Inst Engn & Technol, Dept Biotechnol, Sira Rd, Tumakauru 572106, Karnataka, India
[3] Univ Nacl Autonoma Mexico, Escuela Nacl Estudios Super, Ciencias Agrogenom, Leon 37684, Mexico
[4] Univ Mysore, Dept Studies Microbiol, Mysore 570006, Karnataka, India
[5] Kuvempu Univ, Dept PG Studies & Res Biotechnol & Bioinformat, Shivamogga 577451, Karnataka, India
关键词
Calophyllum tomentosum; AgNPs; Characterization; Antibacterial; Antioxidant; Antidiabetic; LEAF EXTRACT; ALPHA-GLUCOSIDASE; BIOSYNTHESIS;
D O I
10.1016/j.rinp.2018.02.049
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
The current research study is to develop an easy and eco-friendly method for the synthesis of AgNPs using aqueous leaf extract of Calophyllum tomentosum (CtAgNPs) and evaluated the extract to know the effects of anti-bacterial, antioxidant, anti-diabetic, anti-inflammatory and anti-tyrosinase activity. Using UV-vis spectrophotometer, Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), energy dispersive X-ray spectroscopy (EDX) characterized the Calophyllum tomentosum mediated silver nanoparticles. The leaf extract of C. tomentosum yielded flavonoids, saponins, tannins, alkaloids, glycosides, phenols, terpenoids and coumarins. AgNPs formation was confirmed by UV-vis spectra at 438 nm. Crystalline structure with a face centered cubic (fcc) of AgNPs was observed in XRD. FTIR had shown that the phytochemicals were responsible for the reduction and capping material of silver nanoparticles. The size and shape of the AgNPs were determined using SEM. From EDX study analysed the strong absorption property of AgNPs. The CtAgNPs have showed significant antibacterial activity on multi drug resistance bacteria. The CtAgNPs had shown strong antioxidant (DPPH, H2O2 scavenging, nitric oxide scavenging power, reducing power) activities. The CtAgNPs had strongly inhibited the alpha-glucosidase and DPPIV compared to alpha-amylase. The CtAgNPs exhibited strong anti-inflammatory activity (albumin denaturation, membrane stabilization, heat haemolytic, protein inhibitory, lipoxygenase, xanthine oxidase) and tyrosinase inhibitory activity. To our best knowledge, this is the first attempt on the synthesis of silver nanoparticles using Calophyllum tomentosum leaves extract. Hence, to validate our results the in vivo studies at molecular level are needed to develop an antioxidant, anti-diabetic and anti-inflammatory agent. (C) 2018 Published by Elsevier B.V.
引用
收藏
页码:400 / 408
页数:9
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