Glucose Biosensor Based on Nanocomposite Films of CdTe Quantum Dots and Glucose Oxidase

被引：158

作者：

Li, Xinyu ^{[1
]}

Zhou, Yunlong ^{[2
]}

Zheng, Zhaozhu ^{[1
]}

Yue, Xiuli ^{[3
]}

Dai, Zhifei ^{[1
]}

Liu, Shaoqin ^{[1
,4
]}

Tang, Zhiyong ^{[2
]}

机构：

[1] Harbin Inst Technol, Bio X Ctr, Nanomed & Biosensor Lab, Harbin 150080, Peoples R China

[2] Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China

[3] Harbin Inst Technol, Sch Municipal & Environm Engn, Harbin 150001, Peoples R China

[4] Harbin Inst Technol, Ctr Micro & Nanotechnol, Harbin 150080, Peoples R China

来源：

LANGMUIR | 2009年 / 25卷 / 11期

关键词：

CYTOCHROME-C; POLYELECTROLYTE; CDSE; NANOSTRUCTURES; NANOPARTICLES; PERMEABILITY; NANOCRYSTALS; OXIDATION; CHITOSAN; SYSTEMS;

D O I：

10.1021/la900066z

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A blood glucose sensor has been developed based on the multilayer films of CdTe semiconductor quantum dots (QDs) and glucose oxidase (GOD) by using the layer-by-layer assembly technique. When the composite films were contacted with glucose solution, the photoluminescence of QDs in the films was quickly quenched because the enzyme-catalyzed reaction product (H2O2) of GOD and glucose gave rise to the formation of surface defects on QDs. The quenching rate was a function of the concentration of glucose. The linear range and sensitivity for glucose determination could be adjusted by controlling the layers of QDs and GOD. The biosensor was used to successfully deter-mine the concentration of blood glucose in real serum samples without sample pretreatment and exhibited satisfactory reproducibility and accuracy.

引用

页码：6580 / 6586

页数：7

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