Antihypertensive activity of polysaccharide from Crassostrea gigas

被引：20
|
作者：
Wang, Ting [1 ]
Ding, Jie [1 ]
Li, Haibo [1 ]
Xiang, Jingjing [1 ]
Wen, Ping [1 ]
Zhang, Qin [1 ]
Yin, Linliang [2 ]
Jiang, Wei [2 ]
Shen, Caie [3 ]
机构：
[1] Nanjing Med Univ, Affiliated Suzhou Hosp, Ctr Reprod & Genet, 26 Daoqian St, Suzhou 215002, Peoples R China
[2] Nanjing Med Univ, Affiliated Suzhou Hosp, Ultrason Med Ctr, 26 Daoqian St, Suzhou 215002, Peoples R China
[3] Nanjing Med Univ, Affiliated Suzhou Hosp, Hlth Care Dept Women, 26 Daoqian St, Suzhou 215002, Peoples R China
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2016年 / 83卷
关键词：
Polysaccharides; Antihypertensive activity;
D O I：
10.1016/j.ijbiomac.2015.11.078
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Water-soluble polysaccharide was extracted from Crassostrea gigas by hydrolysis with flavourzyme and filtered, ultrafiltered and precipitated using absolute ethanol. Sugar composition analysis performed on the C. gigas polysaccharide (CGP) by high performance liquid chromatography indicated that it was comprised primarily of glucose, and its molecular weight was determined using a TSK-GEL G5000PW column to be similar to 3.413 x 10(6) Da. Next, the antihypertensive activity of CGP was evaluated in rats. Hypertension model Wistar rats were divided into three groups and intragastrically treated with physiological saline (negative control group), CGP (treatment group), and captopril (positive control group). CGP treatment led to significant decrease in both systolic and diastolic pressures in the hypertension model Wistar rats. Furthermore, the antihypertensive effect of CGP was comparable with that of captopril. Thus, CGP has antihypertensive effects and can potentially be used as a therapeutic agent for hypertension. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码：195 / 197
页数：3
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