The role of the basal forebrain adenosine receptors in sleep homeostasis

被引：20

作者：

Gass, Natalia ^{[2
]}

Porkka-Heiskanen, Tarja ^{[2
]}

Kalinchuk, Anna V. ^{[1
,3
]}

机构：

[1] Harvard Univ, Sch Med, Dept Psychiat, Neurosci Lab, W Roxbury, MA 02132 USA

[2] Univ Helsinki, Dept Physiol, Inst Biomed, Helsinki, Finland

[3] VA Boston Healthcare Syst, W Roxbury, MA 02132 USA

来源：

NEUROREPORT | 2009年 / 20卷 / 11期

基金：

芬兰科学院;

关键词：

adenosine; electrophysiology; in vivo microdialysis; sleep deprivation; CENTRAL-NERVOUS-SYSTEM; BEHAVIORAL STATE; A(2A) RECEPTOR; A(1) RECEPTOR; NEURONS; RAT; MICRODIALYSIS; DEPRIVATION; WAKEFULNESS; MODULATION;

D O I：

10.1097/WNR.0b013e32832d5859

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Multiple studies indicate that adenosine released in the basal forebrain during prolonged wakefulness could affect recovery sleep. It is still unclear which of adenosine receptors provide its sleep-modulating effects in the basal forebrain. We infused adenosine A(1) and A(2A) receptors antagonists into the rat basal forebrain during sleep deprivation and compared characteristics of recovery non-rapid eye movement (non-REM) sleep (its amount and non-REM sleep delta power) after sleep deprivation, and after sleep deprivation combined with perfusion of antagonists. A(1) receptor antagonist significantly reduced recovery sleep amount and delta power, whereas A(2A) receptor antagonist had no effect on recovery sleep. We conclude that adenosine can promote recovery non-REM sleep when acting through A(1) receptors in the basal forebrain. NeuroReport 20:1013-1018 (C) 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins.

引用

页码：1013 / 1018

页数：6

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