Alkylation of 2,4-(1H,3H)-Quinazolinediones with Dialkyl Carbonates Under Microwave Irradiations

被引：16

作者：

Alfredo Rivero, Ignacio ^{[1
,2
]}

Guerrero, Leticia ^{[1
]}

Alejandra Espinoza, Karla ^{[3
]}

Cecilia Meza, Martha ^{[1
]}

Ramon Rodriguez, Jesus ^{[3
]}

机构：

[1] Inst Tecnol Tijuana, Ctr Grad & Invest Quim, Tijuana 1166, Mexico

[2] Inst Nacl Invest Nucl, Dept Quim, Mexico City 52750, DF, Mexico

[3] Univ Autonoma Baja California, Fac Quim, Tijuana 22390, BC, Mexico

来源：

MOLECULES | 2009年 / 14卷 / 05期

关键词：

alkylation; quinazoline-2,4-dione; antihypertensive activity; microwaves; MULTIPLE-DRUG RESISTANCE; HETEROCYCLIC COMPOUND; TUMOR-CELLS; METABOLITES; 5-N-ACETYLARDEEMIN; FUMIQUINAZOLINES; FERMENTATION; INHIBITOR; ALKALOIDS; TAXONOMY;

D O I：

10.3390/molecules14051860

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Alkylation is a very important chemical reaction which modifies the biological properties of drugs. Quinazolinedione derivatives are of considerable interest due to their wide array of pharmacological properties. We now report application of a practical alkylation procedure to several quinazolinediones, including pelanserine (5f), which shows antihypertensive properties, 1-methyl-3-(2'-phenylethyl)-1H,3H-quinazoline-2,4-dione (1ab) and 1-methyl-3-[2'-(4'-methoxyphenyl)ethyl]-1H,3H-quinazoline-2,4-dione (1ae), which had been isolated from natural sources. The alkylation was optimized using dimethyl and diethyl carbonates under microwave irradiations.

引用

页码：1860 / 1868

页数：9

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