Absence of cytogenetic effects in children and adults with attention-deficit/hyperactivity disorder treated with methylphenidate

被引：11

作者：

Ponsa, Immaculada ^{[2
,3
,4
]}

Antoni Ramos-Quiroga, Josep ^{[5
,6
]}

Ribases, Marta ^{[5
]}

Bosch, Rosa ^{[5
]}

Bielsa, Anna ^{[5
]}

Teresa Ordeig, Maria ^{[1
]}

Morell, Marta ^{[2
]}

Miro, Rosa ^{[3
,4
]}

de Cid, Rafael ^{[2
,7
,8
]}

Estivill, Xavier ^{[2
,7
,8
]}

Casas, Miquel ^{[5
,6
]}

Bayes, Monica ^{[2
,7
,8
]}

Cormand, Bru ^{[9
,10
,11
]}

Hervas, Amaia ^{[1
]}

机构：

[1] Hosp Mutua Terrassa, Child & Adolescent Mental Hlth Unit, Terrassa, Spain

[2] CRG, Genes & Dis Program, Barcelona, Catalonia, Spain

[3] Univ Autonoma Barcelona, Dept Biol Celular Fisiol & Immunol, Fac Med, Bellaterra, Catalonia, Spain

[4] Univ Autonoma Barcelona, Inst Biotecnol & Biomed, Bellaterra, Catalonia, Spain

[5] Hosp Univ Vall Hebron, Dept Psychiat, Barcelona, Catalonia, Spain

[6] Univ Autonoma Barcelona, Dept Psychiat & Legal Med, Catalonia, Spain

[7] Inst Salud Carlos III, CRG, CIBER Epidemiol & Salud Publ, Barcelona, Catalonia, Spain

[8] Ctr Nacl Genotipado CeGen, Barcelona, Catalonia, Spain

[9] Univ Barcelona, Fac Biol, Dept Genet, Catalonia, Spain

[10] Inst Salud Carlos III, CIBER Enfermedades Raras, Barcelona, Catalonia, Spain

[11] Univ Barcelona, Inst Biomed, Catalonia, Spain

来源：

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 2009年 / 666卷 / 1-2期

关键词：

ADHD; Methylphenidate; Cytogenetic effects; Children; Adult; SISTER-CHROMATID EXCHANGES; HUMAN-LYMPHOCYTES; MICRONUCLEUS FREQUENCY; CHROMOSOME-ABERRATIONS; ITALIAN POPULATION; IN-VITRO; AGE; NONDISJUNCTION; CANCER; DAMAGE;

D O I：

10.1016/j.mrfmmm.2009.03.014

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Attention-deficit/hyperactivity disorder (ADHD) is the most common psychiatric condition with onset in childhood, and in more than 50% of cases it persists into adulthood as a chronic disorder. Over five million methylphenidate (MPH) prescriptions were issued in the USA in 2003, mostly for children. A previous report [R.A. El-Zein, S.Z. Abdel-Rahman, M.J. Hay, M.S. Lopez, M.L. Bondy, D.L. Morris and M.S. Legator Cytogenetic effects in children treated with methylphenidate, Cancer Lett. 230 (2005)284-291.] described the induction of chromosome abnormalities by MPH in children treated for three months, contrary to most of the in vitro and in vivo studies reported since then. We present new relevant information concerning the cytogenetic effects of MPH in children and adults. We include a prospective sample of 12 children and 7 adults with a new diagnosis of ADHD and naive to MPH. We analyzed the cytogenetic effects on peripheral lymphocytes before and three months after starting MPH therapy. The cytogenetic analyses included a cytokinesis-block micronucleus (CBMN) assay, a sister chromatid exchange (SCE) analysis and the determination of chromosome aberrations (CA). Following the same strategy and analyzing the same cytogenetic endpoints that were investigated in the original report [RA. El-Zein, S.Z. Abdel-Rahman, M.J. Hay, M.S. Lopez, M.L. Bondy, D.L. Morris and M.S. Legator Cytogenetic effects in children treated with methylphenidate, Cancer Lett. 230 (2005) 284-291.], we found no evidence of increased frequency of micronuclei, sister chromatid exchanges or chromosome aberrations induced by MPH in children and adult populations. MPH treatment of children and adults with ADHD resulted in no significant genomic damage (as suggested by the three endpoints studied), results that do not support a potential increased risk of cancer after exposure to MPH. (c) 2009 Elsevier B.V. All rights reserved.

引用

页码：44 / 49

页数：6

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