Angiogenesis in gynecological cancers and the options for anti-angiogenesis therapy

被引：59

作者：

Yetkin-Arik, Bahar ^{[1
,2
]}

Kastelein, Arnoud W. ^{[3
]}

Klaassen, Ingeborg ^{[1
,2
]}

Jansen, Charlotte H. J. R. ^{[3
]}

Latul, Yani P. ^{[3
]}

Vittori, Milos ^{[4
]}

Biri, Aydan ^{[5
]}

Kahraman, Korhan ^{[6
]}

Griffioen, Arjan W. ^{[7
]}

Amant, Frederic ^{[8
,9
,10
,11
]}

Lok, Christianne A. R. ^{[9
]}

Schlingemann, Reinier O. ^{[1
,12
]}

van Noorden, Cornelis J. F. ^{[2
,13
]}

机构：

[1] Univ Amsterdam, Amsterdam UMC, Canc Ctr Amsterdam, Ocular Angiogenesis Grp,Dept Ophthalmol,Amsterdam, Meibergdreef 9, Amsterdam, Netherlands

[2] Univ Amsterdam, Amsterdam UMC, Canc Ctr Amsterdam, Dept Med Biol,Amsterdam Cardiovasc Sci, Meibergdreef 9, Amsterdam, Netherlands

[3] Univ Amsterdam, Dept Obstet & Gynaecol, Amsterdam UMC, Meibergdreef 9, Amsterdam, Netherlands

[4] Univ Ljubljana, Biotech Fac, Ljubljana, Slovenia

[5] Koru Ankara Hosp, Dept Obstet & Gynecol, Ankara, Turkey

[6] Bahcesehir Univ, Dept Obstet & Gynecol, Sch Med, Istanbul, Turkey

[7] Canc Ctr Amsterdam, Dept Med Oncol, Angiogenesis Lab, Amsterdam UMC, Amsterdam, Netherlands

[8] Katholieke Univ Leuven, Dept Oncol, Leuven, Belgium

[9] Antoni van Leeuwenhoek, Ctr Gynaecol Oncol, Amsterdam, Netherlands

[10] Netherlands Canc Inst, Ctr Gynaecol Oncol, Amsterdam, Netherlands

[11] Univ Amsterdam, Ctr Gynaecol Oncol, Med Ctr, Amsterdam, Netherlands

[12] Univ Lausanne, Jules Gonin Eye Hosp, Fdn Asile Aveugles, Dept Ophthalmol, Lausanne, Switzerland

[13] Natl Inst Biol, Dept Genet Toxicol & Canc Biol, Ljubljana, Slovenia

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2021年 / 1875卷 / 01期

关键词：

Angiogenesis; Anti-angiogenic therapy; Endothelial cells; Endothelial cell metabolism; Gynecological cancer; Non-tip cells; Tip cells; Tumor microenvironment; Vascular disrupting agents; ENDOTHELIAL GROWTH-FACTOR; PHASE-II TRIAL; RECURRENT OVARIAN-CANCER; SMOOTH-MUSCLE-CELLS; CERVICAL INTRAEPITHELIAL NEOPLASIA; COMBRETASTATIN A4 PHOSPHATE; VASCULAR DISRUPTING AGENTS; SODIUM LY573636 SODIUM; HUMAN CORPUS-LUTEUM; CARCINOMA IN-SITU;

D O I：

10.1016/j.bbcan.2020.188446

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Angiogenesis is required in cancer, including gynecological cancers, for the growth of primary tumors and secondary metastases. Development of anti-angiogenesis therapy in gynecological cancers and improvement of its efficacy have been a major focus of fundamental and clinical research. However, survival benefits of current anti-angiogenic agents, such as bevacizumab, in patients with gynecological cancer, are modest. Therefore, a better understanding of angiogenesis and the tumor microenvironment in gynecological cancers is urgently needed to develop more effective anti-angiogenic therapies, either or not in combination with other therapeutic approaches. We describe the molecular aspects of (tumor) blood vessel formation and the tumor microenvironment and provide an extensive clinical overview of current anti-angiogenic therapies for gynecological cancers. We discuss the different phenotypes of angiogenic endothelial cells as potential therapeutic targets, strategies aimed at intervention in their metabolism, and approaches targeting their (inflammatory) tumor microenvironment.

引用

页数：18

共 361 条

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