Both central command and exercise pressor reflex activate cardiac sympathetic nerve activity in decerebrate cats

被引:23
|
作者
Tsuchimochi, Hirotsugu [1 ]
Hayes, Shawn G. [1 ]
McCord, Jennifer L. [1 ]
Kaufman, Marc P. [1 ]
机构
[1] Penn State Univ, Coll Med, Penn State Heart & Vasc Inst, Hershey, PA 17033 USA
来源
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY | 2009年 / 296卷 / 04期
关键词
mechanoreflex; renal sympathetic nerve activity; group III and IV afferents; STATIC MUSCLE-CONTRACTION; SKELETAL-MUSCLE; DYNAMIC EXERCISE; HEART-RATE; MUSCULAR-CONTRACTION; DIFFERENTIAL CONTROL; TENDON STRETCH; NEURAL-CONTROL; GROUP-III; STIMULATION;
D O I
10.1152/ajpheart.01219.2008
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Tsuchimochi H, Hayes SG, McCord JL, Kaufman MP. Both central command and exercise pressor reflex activate cardiac sympathetic nerve activity in decerebrate cats. Am J Physiol Heart Circ Physiol 296: H1157-H1163, 2009. First published February 20, 2009; doi:10.1152/ajpheart.01219.2008.-Both static and dynamic exercise are known to increase cardiac pump function as well as arterial blood pressure. Feedforward control by central command and feedback control by the exercise pressor reflex are thought to be the neural mechanisms causing these effects during exercise. It remains unknown as to how each mechanism activates cardiac sympathetic nerve activity (CSNA) during exercise, especially at its onset. Thus we examined the response of CSNA to stimulation of the mesencephalic locomotor region (MLR, i.e., central command) and to static muscle contraction of the triceps surae muscles or stretch of the calcaneal tendon in decerebrate cats. We found that MLR stimulation immediately increased CSNA, which was followed by a gradual increase in heart rate, mean arterial pressure, and ventral root activity in a stimulus intensity-dependent manner. The latency of the increase in CSNA from the onset of MLR stimulation ranged from 67 to 387 ms. Both static contraction and tendon stretch also rapidly increased CSNA. Their latency from the development of tension in response to ventral root stimulation ranged from 78 to 670 ms. These findings suggest that both central command and the muscle mechanoreflex play a role in controlling cardiac sympathetic outflow at the onset of exercise.
引用
收藏
页码:H1157 / H1163
页数:7
相关论文
共 50 条
  • [21] CENTRAL COMMAND INCREASES MUSCLE SYMPATHETIC-NERVE ACTIVITY DURING INTENSE INTERMITTENT ISOMETRIC-EXERCISE IN HUMANS
    VICTOR, RG
    SECHER, NH
    LYSON, T
    MITCHELL, JH
    CIRCULATION RESEARCH, 1995, 76 (01) : 127 - 131
  • [22] The Role of Central Command in the Increase in Muscle Sympathetic Nerve Activity to Contracting Muscle During High Intensity Isometric Exercise
    Boulton, Daniel
    Taylor, Chloe E.
    Green, Simon
    Macefield, Vaughan G.
    FRONTIERS IN NEUROSCIENCE, 2021, 15
  • [23] ANESTHETIC EFFECTS ON TONIC AND REFLEX RENAL SYMPATHETIC-NERVE ACTIVITY IN AWAKE CATS
    MATSUKAWA, K
    NINOMIYA, I
    AMERICAN JOURNAL OF PHYSIOLOGY, 1989, 256 (02): : R371 - R378
  • [24] REFLEX CONTROL OF SYMPATHETIC-NERVE ACTIVITY DURING STATIC EXERCISE IN HUMANS
    VICTOR, RG
    MARK, AL
    NERHED, C
    WALLIN, BG
    CIRCULATION, 1984, 70 (04) : 215 - 215
  • [25] Exaggerated pressor and sympathetic nerve responses during spontaneously-occurring motor activity in decerebrate spontaneously hypertensive rats
    Matsukawa, Kanji
    Iwamoto, Gary
    Mitchell, Jere
    Mizuno, Masaki
    Kim, Han-Kyul
    Williamson, Jon
    Smith, Scott
    FASEB JOURNAL, 2021, 35
  • [26] THE EFFECT OF STATIC EXERCISE ON RENAL SYMPATHETIC-NERVE ACTIVITY IN CONSCIOUS CATS
    MATSUKAWA, K
    MITCHELL, JH
    WALL, PT
    WILSON, LB
    JOURNAL OF PHYSIOLOGY-LONDON, 1991, 434 : 453 - 467
  • [27] A sex difference in the cardiac afferent reflex control of renal sympathetic nerve activity
    Barrett, Carolyn J.
    Pinkham, Maximilan I.
    FASEB JOURNAL, 2011, 25
  • [28] REFLEX EFFECTS OF HEPATIC BARORECEPTORS ON RENAL AND CARDIAC SYMPATHETIC-NERVE ACTIVITY
    KOSTREVA, DR
    CASTANER, A
    KAMPINE, JP
    AMERICAN JOURNAL OF PHYSIOLOGY, 1980, 238 (05): : R390 - R394
  • [29] Examining sympathetic nerve activity with microneurography during hypnosis: Untangling the effects of central command
    Robinson, Richard C.
    Crasilneck, Harold
    Garofalo, J. P.
    Whitfill, Travis
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL HYPNOSIS, 2006, 54 (04) : 448 - 456
  • [30] MECHANISM OF CARDIAC-RELATED SYNCHRONIZED CARDIAC SYMPATHETIC-NERVE ACTIVITY IN AWAKE CATS
    NINOMIYA, I
    AKIYAMA, T
    NISHIURA, N
    AMERICAN JOURNAL OF PHYSIOLOGY, 1990, 259 (03): : R499 - R506