Nickel-catalyzed intermolecular [3+2+2] cocyclization of ethyl cyclopropylideneacetate and alkynes

被引:114
作者
Saito, S [1 ]
Masuda, M [1 ]
Komagawa, S [1 ]
机构
[1] Tokyo Univ Sci, Fac Sci, Dept Chem, Shinjuku Ku, Tokyo 1628601, Japan
关键词
D O I
10.1021/ja0494306
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The [3 + 2 + 2] cocyclization of ethyl cyclopropylideneacetate (1a) and terminal alkynes (2) proceeded smoothly in the presence of 10 mol % "Ni(PPh3)2", which was prepared in situ from Ni(cod)2 and PPh3. The high reactivity of 1a, which was induced by the introduction of an electron-withdrawing group, is very important for the progress of this reaction. The cycloheptadiene derivatives were synthesized in highly selective manner in good yields. Copyright © 2004 American Chemical Society.
引用
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页码:10540 / 10541
页数:2
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