Genetics of hyperuricemia and gout: Insights from recent genome-wide association studies and Mendelian randomization studies

被引：4
作者：
Ko, Yu-Lin [1 ,2 ,3 ,4 ,5 ]
机构：
[1] Taipei Tzu Chi Hosp, Buddhist Tzu Chi Med Fdn, Cardiovasc Ctr, New Taipei, Taiwan
[2] Taipei Tzu Chi Hosp, Buddhist Tzu Chi Med Fdn, Dept Internal Med, Div Cardiol, New Taipei, Taiwan
[3] Tzu Chi Univ, Sch Med, Hualien, Taiwan
[4] Taipei Tzu Chi Hosp, Buddhist Tzu Chi Med Fdn, Dept Res, New Taipei, Taiwan
[5] Taipei Tzu Chi Hosp, Buddhist Tzu Chi Med Fdn, Dept Internal Med, Div Cardiol, 289 Jianguo Rd, New Taipei, Taiwan
来源：
TZU CHI MEDICAL JOURNAL | 2022年 / 34卷 / 03期
关键词：
Genetics; Genome-wide association study; Gout; Hyperuricemia; Mendelian randomization study; URIC-ACID LEVELS; SERUM URATE LEVELS; RISK; ABCG2; LOCI; PREVALENCE; VARIANTS; SLC2A9; COMMON; IDENTIFICATION;
D O I：
10.4103/tcmj.tcmj_117_21
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Gout is the most common form of inflammatory arthritis in adults. Elevation serum uric acid (SUA) concentration is known to be the key to gout pathogenesis. Since the first genome-wide association study (GWAS) for SUA was performed in 2007, the number of gene loci known to be associated with hyperuricemia and gout has grown rapidly. GWASs and Mendelian randomization studies have also reported numerous novel results regarding the genetics of hyperuricemia and gout since 2018. We concisely review recent advances in scholarship on the effects of genetics on hyperuricemia and gout risk. We also review data from genetic association studies in Taiwan and perform GWASs of SUA levels among Taiwan Biobank participants.
引用
收藏
页码：261 / 269
页数：9
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