Synthesis of 1,2-amino alcohols via catalytic C-H amidation of sp3 methyl C-H bonds

被引：77

作者：

Kang, Taek ^{[1
,2
]}

Kim, Heejeong ^{[1
,2
]}

Kim, Jeung Gon ^{[1
,2
]}

Chang, Sukbok ^{[1
,2
]}

机构：

[1] Inst for Basic Sci Korea, Ctr Catalyt Hydrocarbon Functionalizat, Taejon 305701, South Korea

[2] Korea Adv Inst Sci & Technol, Dept Chem, Taejon 305701, South Korea

来源：

CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 81期

关键词：

ASYMMETRIC AMINOHYDROXYLATION; INTRAMOLECULAR AMIDATION; DIRECTING GROUPS; AMINO-ACIDS; AMINATION; FUNCTIONALIZATION; ACTIVATION; ALKENES; AZIDES; CHEMOSELECTIVITY;

D O I：

10.1039/c4cc05655h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein a new synthetic route to 1,2-amino alcohols is presented by using C-H amidation of sp(3) methyl C-H bonds as a key step. Readily available alcohols were employed as starting materials after converting them to removable ketoxime chelating groups. Iridium catalysts were found to be effective for the C-H amidation, and LAH reduction was then used to furnish beta-amino alcohol products.

引用

页码：12073 / 12075

页数：3

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