Type III interferons in Hepatitis C virus infection

被引：31

作者：

Boisvert, Maude ^{[1
]}

Shoukry, Naglaa H. ^{[1
,2
]}

机构：

[1] Ctr Hosp Univ Montreal CRCHUM, Ctr Rech, Montreal, PQ, Canada

[2] Univ Montreal, Dept Med, Montreal, PQ, Canada

来源：

FRONTIERS IN IMMUNOLOGY | 2016年 / 7卷

基金：

加拿大健康研究院;

关键词：

hepatitis C; IFN-lambda; 3; 4; liver; SNP; HCV clearance; SVR; RIBAVIRIN COMBINATION THERAPY; GENOME-WIDE ASSOCIATION; IFN-LAMBDA RECEPTOR; GENETIC-VARIATION; SPONTANEOUS CLEARANCE; PEGYLATED INTERFERON; HCV CLEARANCE; HEPATOCELLULAR-CARCINOMA; NEUTRALIZING ANTIBODIES; TREATMENT FAILURE;

D O I：

10.3389/fimmu.2016.00628

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The interferon (IFN)-lambda family of type III cytokines includes the closely related interleukin (IL)-28A (IFN-lambda 2), IL-28B (IFN-lambda 3), and IL-29 (IFN-lambda 1). They signal through the Janus kinases (JAK)-signal transducers and activators of transcription pathway and promote an antiviral state by the induction of expression of several interferon-stimulated genes (ISGs). Contrary to type I IFNs, the effect of IFN-lambda cytokines is largely limited to epithelial cells due to the restricted pattern of expression of their specific receptor. Several genome-wide association studies have established a strong correlation between polymorphism in the region of IL-28B gene (encoding for IFN-lambda 3) and both spontaneous and therapeutic IFN-mediated clearance of hepatitis C virus (HCV) infection, but the mechanism(s) underlying this enhanced viral clearance are not fully understood. IFN-lambda 3 directly inhibits HCV replication, and in vitro studies suggest that polymorphism in the IFN-lambda 3 and its recently identified overlapping IFN-lambda 4 govern the pattern of ISGs induced upon HCV infection of hepatocytes. IFN-lambda can also be produced by dendritic cells, and apart from its antiviral action on hepatocytes, it can regulate the inflammatory response of monocytes/macrophages, thus acting at the interface between innate and adaptive immunity. Here, we review the current state of knowledge about the role of IFN-lambda cytokines in mediating and regulating the immune response during acute and chronic HCV infections.

引用

页数：12

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