A Comparison of Dual Gradient-Echo and Spin-Echo fMRI of the Inferior Temporal Lobe

被引:89
作者
Halai, Ajay D. [1 ]
RWelbourne, Stephen [1 ]
Embleton, Karl [2 ]
Parkes, Laura M. [3 ]
机构
[1] Univ Manchester, Sch Psychol Sci, Neurosci & Aphasia Res Unit, Manchester M13 9PL, Lancs, England
[2] Univ Manchester, Sch Psychol Sci, Cognit & Cognit Neurosci Grp, Manchester M13 9PL, Lancs, England
[3] Univ Manchester, Inst Populat Hlth, Ctr Imaging Sci, Manchester M13 9PL, Lancs, England
关键词
dual echo; spin echo; EPI; magnetic susceptibility; inferior temporal lobe; BOLD-CONTRAST SENSITIVITY; INDUCED SIGNAL LOSSES; SEMANTIC DEMENTIA; OPTIMIZED EPI; PLANAR FMRI; SUSCEPTIBILITY; REDUCTION; COMPENSATION; CORTEX; REPRESENTATION;
D O I
10.1002/hbm.22463
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Magnetic susceptibility differences at tissue interfaces lead to signal loss in conventional gradient-echo (GE) EPI. This poses a problem for fMRI in language and memory paradigms, which activate the most affected regions. Two methods proposed to overcome this are spin-echo EPI and dual GE EPI, where two EPI read-outs are serially collected at a short and longer echo time. The spinecho method applies a refocusing pulse to recover dephased MR signal due to static field inhomogeneities, but is known to have a relatively low blood oxygenation level dependant (BOLD) sensitivity. In comparison, GE has superior BOLD sensitivity, and by employing an additional shorter echo, in a dual GE sequence, it can reduce signal loss due to spin dephasing. We directly compared dual GE and spin-echo fMRI during a semantic categorization task, which has been shown to activate the inferior temporal region-a region known to be affected by magnetic susceptibility. A whole brain analysis showed that the dual GE resulted in significantly higher activation within the left inferior temporal fusiform (ITF) cortex, compared to spin-echo. The inferior frontal gyrus (IFG) was activated for dual GE, but not spin-echo. Regions of interest analysis was carried out on the anterior and posterior ITF, left and right IFG, and part of the cerebellum. Dual GE outperformed spin-echo in the anterior and posterior ITF and bilateral IFG regions, whilst being equal in the cerebellum. Hence, dual GE should be the method of choice for fMRI studies of inferior temporal regions. (c) 2014 Wiley Periodicals, Inc.
引用
收藏
页码:4118 / 4128
页数:11
相关论文
共 57 条
  • [1] SPIN-ECHO AND GRADIENT-ECHO EPI OF HUMAN BRAIN ACTIVATION USING BOLD CONTRAST - A COMPARATIVE-STUDY AT 1.5 T
    BANDETTINI, PA
    WONG, EC
    JESMANOWICZ, A
    HINKS, RS
    HYDE, JS
    [J]. NMR IN BIOMEDICINE, 1994, 7 (1-2) : 12 - 20
  • [2] Improved BOLD detection in the medial temporal region using parallel imaging and voxel volume reduction
    Bellgowan, PSF
    Bandettini, PA
    van Gelderen, P
    Martin, A
    Bodurka, J
    [J]. NEUROIMAGE, 2006, 29 (04) : 1244 - 1251
  • [3] The Ventral and Inferolateral Aspects of the Anterior Temporal Lobe Are Crucial in Semantic Memory: Evidence from a Novel Direct Comparison of Distortion-Corrected fMRI, rTMS, and Semantic Dementia
    Binney, Richard J.
    Embleton, Karl V.
    Jefferies, Elizabeth
    Parker, Geoffrey J. M.
    Ralph, Matthew A. Lambon
    [J]. CEREBRAL CORTEX, 2010, 20 (11) : 2728 - 2738
  • [4] MR CONTRAST DUE TO INTRAVASCULAR MAGNETIC-SUSCEPTIBILITY PERTURBATIONS
    BOXERMAN, JL
    HAMBERG, LM
    ROSEN, BR
    WEISSKOFF, RM
    [J]. MAGNETIC RESONANCE IN MEDICINE, 1995, 34 (04) : 555 - 566
  • [5] REDUCTION OF SUSCEPTIBILITY ARTIFACT IN GRADIENT-ECHO IMAGING
    CHO, ZH
    RO, YM
    [J]. MAGNETIC RESONANCE IN MEDICINE, 1992, 23 (01) : 193 - 200
  • [6] Constable RT, 1999, MAGNET RESON MED, V42, P110, DOI 10.1002/(SICI)1522-2594(199907)42:1<110::AID-MRM15>3.0.CO
  • [7] 2-3
  • [8] Compensation of susceptibility-induced signal loss in echo-planar imaging for functional applications
    Cordes, D
    Turski, PA
    Sorenson, JA
    [J]. MAGNETIC RESONANCE IMAGING, 2000, 18 (09) : 1055 - 1068
  • [9] An evaluation of the use of passive shimming to improve frontal sensitivity in fMRI
    Cusack, R
    Russell, B
    Cox, SML
    De Panfilis, C
    Schwarzbauer, C
    Ansorge, R
    [J]. NEUROIMAGE, 2005, 24 (01) : 82 - 91
  • [10] Positive or negative blips? The effect of phase encoding scheme on susceptibility-induced signal losses in EPI
    De Panfilis, C
    Schwarzbauer, C
    [J]. NEUROIMAGE, 2005, 25 (01) : 112 - 121