Prenatal Exposure to Organophosphate Pesticides and Neurobehavioral Development of Neonates: A Birth Cohort Study in Shenyang, China

被引:67
作者
Zhang, Ying [1 ]
Han, Song [1 ]
Liang, Duohong [1 ]
Shi, Xinzhu [1 ]
Wang, Fengzhi [1 ]
Liu, Wei [2 ]
Zhang, Li [2 ]
Chen, Lixin [2 ]
Gu, Yingzi [2 ]
Tian, Ying [3 ]
机构
[1] Shenyang Med Coll, Sch Publ Hlth, Dept Epidemiol, Shenyang, Peoples R China
[2] Shenyang Med Coll, Cent Hosp, Dept Obstet, Shenyang, Peoples R China
[3] Shanghai Jiao Tong Univ, Sch Med, Shanghai 200030, Peoples R China
基金
中国国家自然科学基金;
关键词
BEHAVIORAL NEUROLOGICAL ASSESSMENT; DIALKYL PHOSPHATE METABOLITES; MEXICAN-AMERICAN CHILDREN; BRAIN-CELL DEVELOPMENT; CHLORPYRIFOS EXPOSURE; PERFORMANCE; POPULATION; SHANGHAI; RESIDUES; DIAZINON;
D O I
10.1371/journal.pone.0088491
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Background: A large amount of organophosphate pesticides (OPs) are used in agriculture in China every year, contributing to exposure of OPs through dietary consumption among the general population. However, the level of exposure to OPs in China is still uncertain. Objective: To investigate the effect of the exposure to OPs on the neonatal neurodevelopment during pregnancy in Shenyang, China. Methods: 249 pregnant women enrolled in the Central Hospital Affiliated to Shenyang Medical College from February 2011 to August 2012. A cohort of the mothers and their neonates participated in the study and information on each subject was obtained by questionnaire. Dialkyl phosphate (DAP) metabolites were detected in the urine of mothers during pregnancy to evaluate the exposure level to OPs. Neonate neurobehavioral developmental levels were assessed according to the standards of the Neonatal Behavioral Neurological Assessment (NBNA). Multiple linear regressions were utilized to analyze the association between pregnancy exposure to OPs and neonatal neurobehavioral development. Results: The geometric means (GM) of urinary metabolites for dimethyl phosphate (DMP), dimethyl thiophosphate (DMTP), diethyl phosphate (DEP), and diethyl thiophosphate (DETP) in pregnant women were 18.03, 8.53, 7.14, and 5.64 mu g/L, respectively. Results from multiple linear regressions showed that prenatal OP exposure was one of the most important factors affecting NBNA scores. Prenatal total DAP concentrations were inversely associated with scores on the NBNA scales.? Additionally, a 10-fold increase in DAP concentrations was associated with a decrease of 1.78 regarding the Summary NBNA (95% CI, -2.12 to -1.45). And there was an estimated 2.11-point difference in summary NBNA scores between neonates in the highest quintile of prenatal OP exposure and the lowest quintile group. Conclusion: The high exposure of pregnant women to OPs in Shenyang, China was the predominant risk factor for neonatal neurobehavioral development.
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页数:10
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