Water-Soluble Triarylboron Compound for ATP Imaging In Vivo Using Analyte-Induced Finite Aggregation

被引：124

作者：

Li, Xiaoyan ^{[1
]}

Guo, Xudong ^{[1
]}

Cao, Lixia ^{[1
]}

Xun, Zhiqing ^{[2
]}

Wang, Shuangqing ^{[1
]}

Li, Shayu ^{[1
]}

Li, Yi ^{[2
]}

Yang, Guoqiang ^{[1
]}

机构：

[1] Chinese Acad Sci, Beijing Natl Lab Mol Sci, Key Lab Photochem, Inst Chem, Beijing 100190, Peoples R China

[2] Chinese Acad Sci, Key Lab Photochem Convers & Optoelect Mat, Tech Inst Phys & Chem, Beijing 100190, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2014年 / 53卷 / 30期

基金：

中国国家自然科学基金;

关键词：

aggregation; cell recognition; fluorescence; imaging agents; molecular recognition; INDUCED EMISSION; RATIONAL DESIGN; SOLID-STATE; FLUORESCENT; NANOPARTICLES; SENSORS; PH;

D O I：

10.1002/anie.201403918

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Adenosine 5'-triphosphate (ATP) is a multifunctional molecule that participates in many important biological processes. Currently, fluorescence indicators for ATP with high performance are in demand. Reported herein is a novel water-soluble triarylboron compound which displays an apparent ATP-dependent fluorescence enhancement when dispersed in water. It can selectively recognize ATP from other bioactive substances in vitro and in vivo. The ATP-induced finite aggregation endows the indicator with appreciable photostability and superior tolerance to environmental electrolytes. This indicator has been successfully applied to the ATP imaging in NIH/3T3 fibroblast cells. The difference in the ATP levels within the membrane and cytosol is clearly visible.

引用

页码：7809 / 7813

页数：5

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